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VIM

VIM蛋白全稱(chēng)波形蛋白,是Ⅲ型中間纖維的主要成分,構(gòu)成細(xì)胞骨架網(wǎng)絡(luò)維持細(xì)胞機(jī)械穩(wěn)定性。VIM在上皮細(xì)胞損傷修復(fù)時(shí)異常升高,促進(jìn)細(xì)胞形態(tài)改變與遷移能力,其過(guò)度表達(dá)被視為上皮-間質(zhì)轉(zhuǎn)化的標(biāo)志物,與乳腺癌、胰腺癌的侵襲轉(zhuǎn)移密切相關(guān)。在纖維化疾病領(lǐng)域,肺、肝組織中的VIM沉積與器官硬化進(jìn)程直接相關(guān),阿爾茨海默病患者腦脊液內(nèi)也檢測(cè)到特異性片段積累。
針對(duì)VIM的治療策略多聚焦于抑制其病理聚合。小分子化合物Withaferin A從天然植物提取,可破壞VIM纖維結(jié)構(gòu),在動(dòng)物模型中有效減緩腫瘤轉(zhuǎn)移和肺纖維化進(jìn)展,但存在肝腎毒性問(wèn)題。單克隆抗體VN-18.2通過(guò)阻斷VIM與細(xì)胞膜整合素互作,已完成黑色素瘤治療的臨床前評(píng)估。近年來(lái)利用CRISPR技術(shù)敲低VIM表達(dá)改善心肌纖維化的研究引發(fā)關(guān)注,其載體遞送效率仍是轉(zhuǎn)化難點(diǎn)。

熱銷(xiāo)產(chǎn)品

Recombinant Human Vimentin (VIM) (CSB-EP025857HUc7)

驗(yàn)證數(shù)據(jù)

CSB-EP025857HUc7

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

VIM Recombinant Monoclonal Antibody (CSB-RA025857MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA025857MA1HU

IHC image of CSB-RA025857MA1HU diluted at 1:40 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Rabbit IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA025857MA1HU

IHC image of CSB-RA025857MA1HU diluted at 1:40 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Rabbit IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA025857MA1HU

Immunofluorescence staining of NIH/3T3 cell with CSB-RA025857MA1HU at 1:40, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human vimentin,VIM ELISA Kit (CSB-E08982h)

驗(yàn)證數(shù)據(jù)

CSB-E08982h 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-E08982h

規(guī)格:96T/48T

靈敏度:7.8 pg/mL

檢測(cè)范圍:31.25 pg/mL-2000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

VIM Antibodies

VIM for Homo sapiens (Human)

VIM for H, M, R

VIM Proteins

VIM Proteins for Mus musculus (Mouse)

VIM Proteins for Rattus norvegicus (Rat)

VIM Proteins for Bos taurus (Bovine)

VIM Proteins for Homo sapiens (Human)

VIM Proteins for Gallus gallus (Chicken)

VIM Proteins for Sus scrofa (Pig)

VIM Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

VIM Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

VIM Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)

VIM Proteins for Mesocricetus auratus (Golden hamster)

VIM Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

VIM Proteins for Pan troglodytes (Chimpanzee)

VIM Proteins for Cyprinus carpio (Common carp)

VIM Proteins for Ovis aries (Sheep)

VIM Proteins for MO-Mus musculus (Mouse)

VIM ELISA Kit

VIM ELISA Kit for Homo sapiens (Human)

VIM ELISA Kit for Rattus norvegicus (Rat)