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EGFR

EGFR,即表皮生長(zhǎng)因子受體,別名HER1、ErbB1,由人類EGFR基因編碼,該基因位于7號(hào)染色體的7p12區(qū)。EGFR是一種I型跨膜糖蛋白,屬于酪氨酸激酶型受體,分子量約為170kDa。
其作用機(jī)制涉及與特定配體如EGF和TGF-α結(jié)合后激活,導(dǎo)致受體發(fā)生同源或異源二聚體化,進(jìn)而引發(fā)酪氨酸自磷酸化和多種下游通路(如MAPK、PI3K/PKB和STAT)的激活,這些信號(hào)通路依次觸發(fā)基因轉(zhuǎn)錄,控制細(xì)胞增生、分化和生存。
EGFR在調(diào)節(jié)細(xì)胞增殖、存活和分化過程中起重要作用,EGFR過表達(dá)或活性過度增加與許多癌癥的發(fā)生發(fā)展有關(guān),包括肺癌、肛門癌和多形性膠質(zhì)母細(xì)胞瘤,是癌癥治療的重要靶點(diǎn)之一。

熱銷產(chǎn)品

Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active) (CSB-MP007479HU)

驗(yàn)證數(shù)據(jù)

CSB-MP007479HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP007479HU

Based on the SEQUEST from database of Mammalian Cell host and target protein, the LC-MS/MS Analysis result of CSB-MP007479HU could indicate that this peptide derived from Mammalian Cell-expressed Homo sapiens (Human) EGFR.

CSB-MP007479HU

Based on the SEQUEST from database of Mammalian Cell host and target protein, the LC-MS/MS Analysis result of CSB-MP007479HU could indicate that this peptide derived from Mammalian Cell-expressed Homo sapiens (Human) EGFR.

CSB-MP007479HU

Measured by its binding ability in a functional ELISA. Immobilized EGFR at 1 μg/ml can bind Anti-EGFR recombinant antibody, the EC50 of human EGFR protein is 2.867-3.571 ng/ml.

CSB-MP007479HU

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

CSB-MP007479HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized EGFR at 1 μg/ml can bind Cetuximab, the EC50 of human EGFR protein is 0.6919-1.047 ng/ml.

CSB-MP007479HU

The purity of EGFR was greater than 95% as determined by SEC-HPLC

EGFR Recombinant Monoclonal Antibody (CSB-RA159341MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA159341MA1HU

IHC image of CSB-RA159341MA1HU diluted at 1:50 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA159341MA1HU

IHC image of CSB-RA159341MA1HU diluted at 1:50 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA159341MA1HU

Overlay Peak curve showing NIH/3T3 cells stained with CSB-RA159341MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-Rabbit IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

EGFR Antibodies

EGFR for Homo sapiens (Human)

EGFR for H

EGFR Proteins

EGFR Proteins for Gallus gallus (Chicken)

EGFR Proteins for Apis mellifera (Honeybee)

EGFR Proteins for Macaca mulatta (Rhesus macaque)

EGFR Proteins for Drosophila melanogaster (Fruit fly)

EGFR Proteins for Homo sapiens (Human)

EGFR ELISA Kit

EGFR ELISA Kit for Homo sapiens (Human)