MSTN
MSTN，即肌生長(zhǎng)抑制素，是一種在哺乳動(dòng)物肌肉骨骼系統(tǒng)中起關(guān)鍵調(diào)控作用的分泌性蛋白，屬于TGF-β超家族成員。其結(jié)構(gòu)包括N-末端的分泌信號(hào)肽和半胱氨酸結(jié)構(gòu)。MSTN通過(guò)與其受體結(jié)合，抑制肌肉細(xì)胞的生長(zhǎng)、分化和增殖，從而調(diào)控肌肉的發(fā)育。在信號(hào)轉(zhuǎn)導(dǎo)過(guò)程中，MSTN與胞質(zhì)內(nèi)受體形成復(fù)合物，進(jìn)而激活Smads蛋白，使其磷酸化并進(jìn)入細(xì)胞核調(diào)節(jié)靶基因表達(dá)。此外，MSTN還涉及MAPK和p38等信號(hào)通路的轉(zhuǎn)導(dǎo)，對(duì)肌肉細(xì)胞增殖周期產(chǎn)生影響。MSTN的復(fù)雜結(jié)構(gòu)和功能使其在生物學(xué)和醫(yī)學(xué)領(lǐng)域具有廣泛的應(yīng)用前景，尤其在肌肉生長(zhǎng)調(diào)控、疾病治療及肉化劑開(kāi)發(fā)等方面。
熱銷(xiāo)產(chǎn)品
Recombinant Human Growth/differentiation factor 8 (MSTN) (Active) (CSB-MP015057HU(A4))
驗(yàn)證數(shù)據(jù)
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(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Activity
Measured by its binding ability in a functional ELISA. Immobilized Human MSTN(GDF-8) at 2 μg/ml can bind Human ACVR2B (CSB-MP623829HUi9). The EC50 is 68.26-74.59 ng/mL.
MSTN Antibody (CSB-PA11869A0Rb)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: 293T whole cell lysate, Hela whole cell lysate, U251 whole cell lysate
All lanes: MSTN antibody at 4µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 43 kDa
Observed band size: 43 kDa
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA11869A0Rb at dilution of 1:100
Human Myostatin,MSTN ELISA Kit (CSB-E11300h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E11300h
規(guī)格：96T/48T
靈敏度：0.312 ng/mL
檢測(cè)范圍：0.625 ng/mL-20 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
MSTN Antibodies
MSTN for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA015057GA01HU | MSTN Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA11869A0Rb | MSTN Antibody | Human | ELISA, WB, IHC |
| CSB-PA11869B0Rb | MSTN Antibody, HRP conjugated | Human | ELISA |
| CSB-PA008776 | MSTN Antibody | Human,Mouse | IHC, ELISA |
| CSB-PA293957 | MSTN Antibody | Human,Mouse,Rat | ELISA,IHC |
MSTN Proteins
MSTN Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP015057HU CSB-BP015057HU CSB-EP015057HU-B |
Recombinant Human Growth/differentiation factor 8 (MSTN) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP015057HU | Recombinant Human Growth/differentiation factor 8 (MSTN) | E.coli |
| CSB-MP015057HU(A4) | Recombinant Human Growth/differentiation factor 8 (MSTN) (Active) | Mammalian cell |
| CSB-EP015057HUd7 | Recombinant Human Growth/differentiation factor 8 (MSTN) | E.coli |
MSTN ELISA Kit
MSTN ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-E11300h | Human Myostatin,MSTN ELISA Kit | serum, plasma, tissue homogenates | 0.312 ng/mL |
