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TM4SF1

TM4SF1(Transmembrane 4 L six family member 1)是Tetraspanin超家族中亞家族TM4SFs的一員,首次于1986年被鑒定。它具有Tetraspanin家族典型的四次跨膜結(jié)構(gòu),胞外含兩個loop區(qū)EC1和EC2,其中EC2區(qū)可通過半胱氨酸殘基與整合素α5β1結(jié)合,影響細胞的黏附和運動。C端胞質(zhì)區(qū)包含PDZ結(jié)合域,可與Syntenin-1和Syntenin-2蛋白相互作用介導(dǎo)腫瘤細胞的增殖和轉(zhuǎn)移。 TM4SF1在多種腫瘤細胞表面高表達,包括肺癌、乳腺癌、肝癌、結(jié)直腸癌及卵巢癌等,且能與脂質(zhì)激酶、酪氨酸蛋白激酶等形成復(fù)合體,如可結(jié)合DDR1,激活PKC和JAK2-STAT3信號通路,促進細胞偽足延伸。初步的研究結(jié)果表明,TM4SF1作為具有酪氨酸蛋白激酶活性的單次跨膜受體1(DDR1)的輔助受體,調(diào)控下游的PKC/STAT3信號通路,從而影響乳腺癌向肺組織的轉(zhuǎn)移。此外,TM4SF1也是具有新型內(nèi)化途徑的ADC靶點,這意味著它在抗體偶聯(lián)藥物(ADC)的設(shè)計和開發(fā)中可能具有潛在的應(yīng)用價值。 于TM4SF1的藥物研發(fā)處于初級階段,尚未有成熟的藥物應(yīng)用于臨床治療。因此,對于TM4SF1的研究仍具有深遠的意義和廣闊的前景。

熱銷產(chǎn)品

Recombinant Human Transmembrane 4 L6 family member 1(TM4SF1)-VLPs (Active)

驗證數(shù)據(jù)

WB
CSB-MP023615HU WB

CSB-MP023615HU is detected by Mouse anti-6*His monoclonal antibody.The two bands respectively correspond to monomer, Homodimer.

ELISA
CSB-MP023615HU ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TM4SF1 at 5μg/mL can bind Anti-TM4SF1 recombinant antibody(CSB-RA023615MA1HU), the EC50 is 4.079-4.472 ng/mL.VLPs (CSB-MP3838) is negative control.

HPLC
CSB-MP023615HU HPLC

The purity of VLPs was greater than 95% as determined by SEC-HPLC.

Recombinant Macaca fascicularis Transmembrane 4 L6 family member 1 (TM4SF1)-VLPs (Active)

驗證數(shù)據(jù)

WB
CSB-MP5031MOV WB

CSB-MP5031MOV is detected by Mouse anti-6*His monoclonal antibody.The two bands respectively correspond to monomer, Homodimer.

ELISA
CSB-MP5031MOV ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus TM4SF1 at 5μg/mL can bind Anti-TM4SF1 recombinant antibody(CSB-RA023615MA1HU), the EC50 is 4.480-4.930 ng/mL.VLPs (CSB-MP3838) is negative control.

HPLC
CSB-MP5031MOV HPLC

The purity of VLPs was greater than 95% as determined by SEC-HPLC


TM4SF1 Antibodies

TM4SF1 for Homo sapiens (Human)

TM4SF1 Proteins

TM4SF1 Proteins for Homo sapiens (Human)