TSPAN8
TSPAN8，別名CO-029/TM4SF3。它是一種四跨膜蛋白超家族(TM4SF)的成員，主要在多種腫瘤中高表達，并可能通過促進血管再生以及增強腫瘤細胞遷移和侵襲等促進腫瘤的轉(zhuǎn)移與進展。TSPAN8的作用機制與其在細胞膜上的定位有關(guān)，它可以通過形成同源或異源二聚體與其他蛋白質(zhì)分子在質(zhì)膜上形成多聚體復(fù)合物，從而發(fā)揮功能。此外，TSPAN8還可以通過與非整合素伴侶如EWI-F、EPCAM、CD13、PKC和PI4KII等相互結(jié)合。TSPAN8在生物學(xué)上的意義主要體現(xiàn)在其對腫瘤發(fā)生發(fā)展中的調(diào)控作用。研究發(fā)現(xiàn)，TSPAN8在乳腺癌進展中EGF/EGFR信號通路被激活，通過SOX9上調(diào)TSPAN8轉(zhuǎn)錄。TSPAN8的高表達與腫瘤干細胞的特性相關(guān)，并且與治療抵抗和不良預(yù)后有關(guān)。TSPAN8還可以通過激活PI3K-AKT信號通路增強癌細胞的抗凋亡能力。此外，TSPAN8的表達還與腫瘤微環(huán)境中的細胞間通訊有關(guān)，它在外泌體中富集，可能通過細胞外囊泡在細胞間進行信號傳遞，影響腫瘤轉(zhuǎn)移。因此，TSPAN8是腫瘤治療中的一個潛在靶點。
熱銷產(chǎn)品
TSPAN8 Recombinant Monoclonal Antibody (CSB-RA025166MA1HU)
驗證數(shù)據(jù)
The Binding Activity of TSPAN8 with Anti-TSPAN8 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TSPAN8 (CSB-MP025166HU) at 5 μg/mL can bind Anti-TSPAN8 recombinant antibody. The EC50 is 2.261-2.623 ng/mL.The VLPs (CSB-MP3838) is negative control.
Untransfected MC38 cells (green line) and transfected Human TSPAN8 MC38 stable cells (red line) were stained with anti-TSPAN8 antibody (CSB-RA025166MA1HU) (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
The purity of TSPAN8 was greater than 95% as determined by SEC-HPLC
TSPAN8 Antibodies
TSPAN8 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA163150 | TSPAN8 Antibody | Human | ELISA,WB,IF |
| CSB-PA004260 | TSPAN8 Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA025166LA01HU | TSPAN8 Antibody | Human | ELISA, IHC, IF |
| CSB-PA025166LB01HU | TSPAN8 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA025166LC01HU | TSPAN8 Antibody, FITC conjugated | Human | |
| CSB-PA025166LD01HU | TSPAN8 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA025166MA1HU | TSPAN8 Recombinant Monoclonal Antibody | Human | ELISA, FC |
| CSB-RA025166MA2HU | TSPAN8 Recombinant Monoclonal Antibody | Human | FC |
| CSB-RA025166MA3HU | TSPAN8 Recombinant Monoclonal Antibody | Human | FC |
TSPAN8 Proteins
TSPAN8 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025166HU1 CSB-EP025166HU1 CSB-BP025166HU1 CSB-MP025166HU1 CSB-EP025166HU1-B |
Recombinant Human Tetraspanin-8 (TSPAN8), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF025166HU | Recombinant Human Tetraspanin-8 (TSPAN8) | in vitro E.coli expression system |
| CSB-MP025166HU | Recombinant Human Tetraspanin-8 (TSPAN8)-VLPs (Active) | Mammalian cell |
