SPARC
SPARC，全稱為分泌性酸性富含半胱氨酸蛋白，廣泛分布于人體細胞外基質(zhì)中。這種蛋白如同"動態(tài)膠水"，通過與膠原等成分互動調(diào)節(jié)細胞行為，既能維持組織穩(wěn)態(tài)，又在創(chuàng)傷修復中扮演雙刃劍角色。例如，在惡性腫瘤中，SP過量分泌可能幫助癌細胞突破周圍屏障，促進轉(zhuǎn)移擴散；而在慢性肝病或肺病中，它卻成為推動膠原異常堆積、引發(fā)器官纖維化的"隱形推手"。SPARC的表達失調(diào)不僅與乳腺癌、結(jié)直腸癌的侵襲性相關(guān)，還涉及糖尿病血管病變和動脈硬化斑塊的形成。針對這些特性，研究人員正在開發(fā)兩類干預手段：一類是抑制性抗體藥物，試圖阻斷其在腫瘤微環(huán)境中的促轉(zhuǎn)移作用，目前已有候選藥物完成動物實驗；另一類則利用組織再生的特性，將重組SPARC蛋白與仿生材料結(jié)合，用于燒傷創(chuàng)面修復的臨床試驗。盡管其復雜功能仍需深入解析，但SPARC已展現(xiàn)出從癌癥到再生醫(yī)學的跨領(lǐng)域治療潛力。
熱銷產(chǎn)品
Recombinant Human SPARC (SPARC) (CSB-RP094444h)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗證數(shù)據(jù)
Western Blot analysis of HeLa HepG2 cells using SPARC Polyclonal Antibody
Human osteonectin,ON ELISA Kit (CSB-EL022486HU)
驗證數(shù)據(jù)
貨號：CSB-EL022486HU
規(guī)格：96T/48T
靈敏度：15.6 ng/mL
檢測范圍：62.5 ng/mL-4000 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
SPARC Antibodies
SPARC for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA022486GA01HU | SPARC Antibody | Human,Mouse,Rat,Pig | ELISA,WB,IHC |
| CSB-PA189204 | SPARC Antibody | Human | ELISA,WB |
| CSB-PA006034 | SPARC Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA785325 | SPARC Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA190682 | SPARC Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
SPARC Proteins
SPARC Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022486BO CSB-BP022486BO CSB-MP022486BO CSB-EP022486BO-B |
Recombinant Bovine SPARC (SPARC) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPARC Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022486PI CSB-EP022486PI CSB-BP022486PI CSB-MP022486PI CSB-EP022486PI-B |
Recombinant Pig SPARC (SPARC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPARC Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022486CH CSB-EP022486CH CSB-BP022486CH CSB-MP022486CH CSB-EP022486CH-B |
Recombinant Chicken SPARC (SPARC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPARC Proteins for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022486RB CSB-EP022486RB CSB-BP022486RB CSB-MP022486RB CSB-EP022486RB-B |
Recombinant Rabbit SPARC (SPARC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPARC Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022486HU CSB-EP022486HU CSB-BP022486HU CSB-MP022486HU CSB-EP022486HU-B |
Recombinant Human SPARC (SPARC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-RP094444h | Recombinant Human SPARC (SPARC) | E.coli |
| CSB-AP000311HU | Recombinant Human SPARC protein (SPARC) | E.Coli |
| CSB-AP000301HU | Recombinant Human SPARC protein (SPARC), partial (Active) | E.Coli |
SPARC Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022486MO CSB-EP022486MO CSB-BP022486MO CSB-MP022486MO CSB-EP022486MO-B |
Recombinant Mouse SPARC (Sparc) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPARC Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022486RA CSB-EP022486RA CSB-BP022486RA CSB-MP022486RA CSB-EP022486RA-B |
Recombinant Rat SPARC (Sparc) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPARC Proteins for Mustela vison (American mink) (Neovison vison)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022486MVE CSB-EP022486MVE CSB-BP022486MVE CSB-MP022486MVE CSB-EP022486MVE-B |
Recombinant Mustela vison SPARC (SPARC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPARC Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022486XBE CSB-EP022486XBE CSB-BP022486XBE CSB-MP022486XBE CSB-EP022486XBE-B |
Recombinant Xenopus laevis SPARC (sparc) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPARC Proteins for Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022486DXJ CSB-EP022486DXJ CSB-BP022486DXJ CSB-MP022486DXJ CSB-EP022486DXJ-B |
Recombinant Coturnix coturnix japonica SPARC (SPARC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPARC Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP712861PYX CSB-EP712861PYX CSB-BP712861PYX CSB-MP712861PYX CSB-EP712861PYX-B |
Recombinant Pongo abelii SPARC (SPARC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPARC ELISA Kit
SPARC ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL022486HU | Human osteonectin,ON ELISA Kit | serum, plasma, tissue homogenates, urine | 15.6 ng/mL |
SPARC ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E08762m | Mouse osteonectin,ON ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 7.81 pg/mL |
