PCNA
PCNA，全稱為增殖細胞核抗原，是一種分子量為36KD的核蛋白，常見別名為Proliferating Cell Nuclear Antigen。它作為DNA多聚酶“δ”的輔助蛋白，在真核細胞DNA合成過程中扮演著不可或缺的角色。PCNA參與調節(jié)細胞增殖、DNA修復等多個生理過程，是生物標志物和治療靶點。研究表明，PCNA的缺失會導致小鼠胚胎致死，而特定突變體也無法彌補其在生殖與免疫功能上的缺失，凸顯了其在DNA修復、細胞增殖及免疫反應中的重要性。PCNA在多種癌癥中過度表達，成為癌癥研究與治療的重要靶點。近年來，PCNA抑制劑被發(fā)現能選擇性地殺死腫瘤細胞，而對非惡性細胞無顯著影響，為癌癥治療提供了新思路。目前，已有多個PCNA抑制劑進入臨床試驗階段，如AOH1996和ATX-101，顯示出良好的抗癌活性。這些進展為PCNA的應用和研究開辟了新的方向，為抗癌藥物的研發(fā)提供了新機遇。
熱銷產品
Recombinant Human Proliferating cell nuclear antigen (PCNA) (CSB-EP017621HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PCNA Recombinant Monoclonal Antibody (CSB-RA017621MA1HU)
驗證數據
Overlay Peak curve showing JK cells stained with CSB-RA017621MA1HU (red line) at 1:300. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10, 000 events was performed.
PCNA Antibodies
PCNA for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA017621GA01HU | PCNA Antibody | Human,Mouse,Rat,Zebrafish | ELISA,WB,IHC,IF |
| CSB-PA974334 | PCNA Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA003719 | PCNA Antibody | Human,Mouse,Rat,Monkey | WB, IHC, ELISA |
| CSB-PA01567A0Rb | PCNA Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA01567B0Rb | PCNA Antibody, HRP conjugated | Human | ELISA |
| CSB-PA01567C0Rb | PCNA Antibody, FITC conjugated | Human | |
| CSB-PA01567D0Rb | PCNA Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA017621MA1HU | PCNA Recombinant Monoclonal Antibody | Human | ELISA, FC |
PCNA for H, R, M
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-MA000186 | PCNA Monoclonal Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
PCNA for Arabidopsis thaliana
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA878702LA01DOA | PCNA Antibody | Arabidopsis thaliana | ELISA, WB |
| CSB-PA878702LC01DOA | PCNA Antibody, FITC conjugated | Arabidopsis thaliana | |
| CSB-PA878702LD01DOA | PCNA Antibody, Biotin conjugated | Arabidopsis thaliana | ELISA |
PCNA Proteins
PCNA Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017621HU CSB-BP017621HU CSB-MP017621HU CSB-EP017621HU-B |
Recombinant Human Proliferating cell nuclear antigen (PCNA) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP017621HU | Recombinant Human Proliferating cell nuclear antigen (PCNA) | E.coli |
PCNA Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017621MO CSB-EP017621MO CSB-BP017621MO CSB-MP017621MO CSB-EP017621MO-B |
Recombinant Mouse Proliferating cell nuclear antigen (Pcna) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCNA Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017621RA CSB-EP017621RA CSB-BP017621RA CSB-MP017621RA CSB-EP017621RA-B |
Recombinant Rat Proliferating cell nuclear antigen (Pcna) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCNA Proteins for Bombyx mori (Silk moth)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017621BTT CSB-EP017621BTT CSB-BP017621BTT CSB-MP017621BTT CSB-EP017621BTT-B |
Recombinant Bombyx mori Proliferating cell nuclear antigen (PCNA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCNA Proteins for Sarcophaga crassipalpis
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017621SXH CSB-EP017621SXH CSB-BP017621SXH CSB-MP017621SXH CSB-EP017621SXH-B |
Recombinant Sarcophaga crassipalpis Proliferating cell nuclear antigen (PCNA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCNA Proteins for Pisum sativum (Garden pea)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017621EWE CSB-EP017621EWE CSB-BP017621EWE CSB-MP017621EWE CSB-EP017621EWE-B |
Recombinant Pisum sativum Proliferating cell nuclear antigen (PCNA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCNA Proteins for Nicotiana tabacum (Common tobacco)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017621NHE CSB-EP017621NHE CSB-BP017621NHE CSB-MP017621NHE CSB-EP017621NHE-B |
Recombinant Nicotiana tabacum Proliferating cell nuclear antigen (PCNA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCNA Proteins for Xenopus laevis (African clawed frog)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017621XBE CSB-EP017621XBE CSB-BP017621XBE CSB-MP017621XBE CSB-EP017621XBE-B |
Recombinant Xenopus laevis Proliferating cell nuclear antigen (pcna) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCNA Proteins for Drosophila melanogaster (Fruit fly)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017621DLU CSB-EP017621DLU CSB-BP017621DLU CSB-MP017621DLU CSB-EP017621DLU-B |
Recombinant Drosophila melanogaster Proliferating cell nuclear antigen (mus209) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCNA Proteins for Plasmodium falciparum (isolate K1 / Thailand)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017621EWT CSB-EP017621EWT CSB-BP017621EWT CSB-MP017621EWT CSB-EP017621EWT-B |
Recombinant Plasmodium falciparum Proliferating cell nuclear antigen (PCNA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCNA Proteins for Styela clava (Sea squirt)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017621FOV CSB-EP017621FOV CSB-BP017621FOV CSB-MP017621FOV CSB-EP017621FOV-B |
Recombinant Styela clava Proliferating cell nuclear antigen (PCNA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCNA Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017621DXU CSB-EP017621DXU CSB-BP017621DXU CSB-MP017621DXU CSB-EP017621DXU-B |
Recombinant Cricetulus griseus Proliferating cell nuclear antigen (PCNA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCNA Proteins for Plasmodium falciparum (isolate 3D7)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017621EWP CSB-EP017621EWP CSB-BP017621EWP CSB-MP017621EWP CSB-EP017621EWP-B |
Recombinant Plasmodium falciparum Proliferating cell nuclear antigen (PCNA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCNA Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017621MOV CSB-EP017621MOV CSB-BP017621MOV CSB-MP017621MOV CSB-EP017621MOV-B |
Recombinant Macaca fascicularis Proliferating cell nuclear antigen (PCNA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCNA Proteins for Autographa californica nuclear polyhedrosis virus (AcMNPV)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP318812ARA CSB-EP318812ARA CSB-BP318812ARA CSB-MP318812ARA CSB-EP318812ARA-B |
Recombinant Autographa californica nuclear polyhedrosis virus Probable DNA polymerase sliding clamp (PCNA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCNA Proteins for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP517500OEU CSB-EP517500OEU CSB-BP517500OEU CSB-MP517500OEU CSB-EP517500OEU-B |
Recombinant Orgyia pseudotsugata multicapsid polyhedrosis virus Probable DNA polymerase sliding clamp (PCNA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCNA Proteins for Dictyostelium discoideum (Slime mold)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017621DKK CSB-EP017621DKK CSB-BP017621DKK CSB-MP017621DKK CSB-EP017621DKK-B |
Recombinant Dictyostelium discoideum Proliferating cell nuclear antigen (pcna) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCNA Proteins for Haplochromis burtoni (Burton's mouthbrooder)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017621HSH CSB-EP017621HSH CSB-BP017621HSH CSB-MP017621HSH CSB-EP017621HSH-B |
Recombinant Haplochromis burtoni Proliferating cell nuclear antigen (pcna) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCNA Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017621DIL CSB-EP017621DIL CSB-BP017621DIL CSB-MP017621DIL CSB-EP017621DIL-B |
Recombinant Danio rerio Proliferating cell nuclear antigen (pcna) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCNA Proteins for Gallus gallus (Chicken)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017621CH CSB-EP017621CH CSB-BP017621CH CSB-MP017621CH CSB-EP017621CH-B |
Recombinant Chicken Proliferating cell nuclear antigen (PCNA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCNA Proteins for Populus nigra (Lombardy poplar)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017621PPT CSB-EP017621PPT CSB-BP017621PPT CSB-MP017621PPT CSB-EP017621PPT-B |
Recombinant Populus nigra Proliferating cell nuclear antigen (PCNA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCNA Proteins for Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017621DXJ CSB-EP017621DXJ CSB-BP017621DXJ CSB-MP017621DXJ CSB-EP017621DXJ-B |
Recombinant Coturnix coturnix japonica Proliferating cell nuclear antigen (PCNA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCNA Proteins for Anguilla japonica (Japanese eel)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017621BZH CSB-EP017621BZH CSB-BP017621BZH CSB-MP017621BZH CSB-EP017621BZH-B |
Recombinant Anguilla japonica Proliferating cell nuclear antigen (pcna) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCNA Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017621BO CSB-EP017621BO CSB-BP017621BO CSB-MP017621BO CSB-EP017621BO-B |
Recombinant Bovine Proliferating cell nuclear antigen (PCNA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCNA Proteins for Zea mays (Maize)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017621ZAX CSB-EP017621ZAX CSB-BP017621ZAX CSB-MP017621ZAX CSB-EP017621ZAX-B |
Recombinant Zea mays Proliferating cell nuclear antigen (PCNA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCNA Proteins for Acanthamoeba polyphaga mimivirus (APMV)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP745851ADAZ CSB-EP745851ADAZ CSB-BP745851ADAZ CSB-MP745851ADAZ CSB-EP745851ADAZ-B |
Recombinant Acanthamoeba polyphaga mimivirus Probable DNA polymerase sliding clamp (PCNA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PCNA Proteins for Arabidopsis thaliana (Mouse-ear cress)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP878702DOA CSB-EP878702DOA CSB-BP878702DOA CSB-MP878702DOA CSB-EP878702DOA-B |
Recombinant Arabidopsis thaliana Proliferating cellular nuclear antigen 1 (PCNA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
