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VHL

von Hippel-Lindau disease tumor suppressor is a protein in humans that is encoded by VHL gene. Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.

VHL Antibodies

VHL for Homo sapiens (Human)

VHL Proteins

VHL Proteins for Mus musculus (Mouse)

VHL Proteins for Homo sapiens (Human)

VHL Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

VHL Proteins for Rattus norvegicus (Rat)

VHL Proteins for Drosophila melanogaster (Fruit fly)