VAMP2
VAMP2，即囊泡相關(guān)膜蛋白2，別名synaptobrevin-2。它是一種在神經(jīng)遞質(zhì)釋放過程中起關(guān)鍵作用的蛋白質(zhì)，主要在神經(jīng)系統(tǒng)特異表達(dá)。VAMP2作為可溶性細(xì)胞膜的關(guān)鍵成分之一，參與形成SNARE（可溶性細(xì)胞膜因子附著蛋白受體）復(fù)合體，與syntaxin-1A和SNAP-25結(jié)合產(chǎn)生誘導(dǎo)融合孔形成的力量，從而介導(dǎo)突觸小泡的融合和神經(jīng)遞質(zhì)的釋放。VAMP2在生物學(xué)上的意義非常重大，它不僅參與神經(jīng)遞質(zhì)的正常釋放，影響神經(jīng)系統(tǒng)的信號傳遞，還與多種神經(jīng)退行性疾病和精神疾病的發(fā)生發(fā)展有關(guān)。VAMP2的活性受到多種因素的精細(xì)調(diào)控，包括蛋白質(zhì)、脂質(zhì)、代謝離子等。研究表明，VAMP2在不同區(qū)域的突觸小泡膜上展現(xiàn)出不同的構(gòu)象，膽固醇豐富的微域?qū)ζ錁?gòu)象和SNARE組裝有重要影響。此外，VAMP2的膜結(jié)合特性和活性狀態(tài)在突觸前細(xì)胞質(zhì)中受到嚴(yán)格調(diào)控，這對于神經(jīng)遞質(zhì)釋放的時空精度至關(guān)重要。
熱銷產(chǎn)品
Recombinant Human Vesicle-associated membrane protein 2 (VAMP2) (CSB-EP025781HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP025781HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) VAMP2.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP025781HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) VAMP2.
驗證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA055935(VAMP2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA055935(VAMP2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
Gel: 12%SDS-PAGE,Lysate: 40 μg,Lane 1-3: Human fetal brain tissue, Mouse brain tissue, Hela cells,Primary antibody: CSB-PA055935(VAMP2 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 30 seconds
VAMP2 Antibodies
VAMP2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA025781GA01HU | VAMP2 Antibody | Human,Mouse,Rat | ELISA |
| CSB-PA025781ESR2HU | VAMP2 Antibody | Human | ELISA, IHC |
VAMP2 Proteins
VAMP2 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025781BO1 CSB-EP025781BO1 CSB-BP025781BO1 CSB-MP025781BO1 CSB-EP025781BO1-B |
Recombinant Bovine Vesicle-associated membrane protein 2 (VAMP2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF025781BO | Recombinant Bovine Vesicle-associated membrane protein 2 (VAMP2) | in vitro E.coli expression system |
VAMP2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025781RA1 CSB-BP025781RA1 CSB-MP025781RA1 CSB-EP025781RA1-B |
Recombinant Rat Vesicle-associated membrane protein 2 (Vamp2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF025781RA | Recombinant Rat Vesicle-associated membrane protein 2 (Vamp2) | in vitro E.coli expression system |
| CSB-EP025781RA1 | Recombinant Rat Vesicle-associated membrane protein 2 (Vamp2), partial | E.coli |
VAMP2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025781MO1 CSB-EP025781MO1 CSB-BP025781MO1 CSB-MP025781MO1 CSB-EP025781MO1-B |
Recombinant Mouse Vesicle-associated membrane protein 2 (Vamp2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF025781MO | Recombinant Mouse Vesicle-associated membrane protein 2 (Vamp2) | in vitro E.coli expression system |
VAMP2 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025781XBE1 CSB-EP025781XBE1 CSB-BP025781XBE1 CSB-MP025781XBE1 CSB-EP025781XBE1-B |
Recombinant Xenopus laevis Vesicle-associated membrane protein 2 (vamp2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF025781XBE | Recombinant Xenopus laevis Vesicle-associated membrane protein 2 (vamp2) | in vitro E.coli expression system |
VAMP2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025781HU1 CSB-BP025781HU1 CSB-MP025781HU1 CSB-EP025781HU1-B |
Recombinant Human Vesicle-associated membrane protein 2 (VAMP2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP025781HU | Recombinant Human Vesicle-associated membrane protein 2 (VAMP2) | E.coli |
| CSB-CF025781HU | Recombinant Human Vesicle-associated membrane protein 2 (VAMP2) | in vitro E.coli expression system |
VAMP2 Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP889016MOW CSB-EP889016MOW CSB-BP889016MOW CSB-MP889016MOW CSB-EP889016MOW-B |
Recombinant Macaca mulatta Vesicle-associated membrane protein 2 (VAMP2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
