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SMURF2

E3 ubiquitin-protein ligase SMURF2 is a protein in humans that is encoded by SMURF2 gene. E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2.

SMURF2 Antibodies

SMURF2 for Homo sapiens (Human)

SMURF2 Proteins

SMURF2 Proteins for Mus musculus (Mouse)

SMURF2 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

SMURF2 Proteins for Xenopus laevis (African clawed frog)

SMURF2 Proteins for Homo sapiens (Human)