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RRAGA

RRAGA,別名FIP1、RAGA、FIP-1。RRAGA由人類RRAGA基因編碼,該基因位于9號(hào)染色體的p22.1位置。RRAGA是一種G蛋白,具有GTP結(jié)合活性,能夠與RagC/RRAGC或RagD/RRAGD形成異二聚體Rag復(fù)合物,并在細(xì)胞對(duì)氨基酸饑餓的響應(yīng)、自噬的負(fù)調(diào)控以及TORC1信號(hào)的正調(diào)控中發(fā)揮作用。RRAGA通過(guò)與GATOR1復(fù)合物共定位,在溶酶體和細(xì)胞核中活躍,參與調(diào)節(jié)mTORC1信號(hào)通路。RRAGA在細(xì)胞生長(zhǎng)、代謝和疾病中扮演重要角色,特別是在氨基酸感應(yīng)和mTORC1信號(hào)傳導(dǎo)中。RRAGA的異常表達(dá)或功能失調(diào)與多種疾病相關(guān),包括腫瘤和代謝性疾病。

熱銷產(chǎn)品

Recombinant Human Ras-related GTP-binding protein A (RRAGA), partial (CSB-RP034654h)

驗(yàn)證數(shù)據(jù)

CSB-RP034654h

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

RRAGA Antibody (CSB-PA03465A0Rb)

驗(yàn)證數(shù)據(jù)

CSB-PA03465A0Rb

Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA03465A0Rb at dilution of 1:100

CSB-PA03465A0Rb

Immunofluorescence staining of A549 cells with CSB-PA03465A0Rb at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

RRAGA Antibodies

RRAGA for Homo sapiens (Human)

RRAGA Proteins

RRAGA Proteins for Homo sapiens (Human)

RRAGA Proteins for Bos taurus (Bovine)

RRAGA Proteins for Rattus norvegicus (Rat)

RRAGA Proteins for Mus musculus (Mouse)