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PRKACA

PRKACA,cAMP-dependent protein kinase catalytic subunit alpha,別名PKCA1、Cs-PKA等。PRKACA是蛋白激酶A(PKA)的α催化亞基,PKA是一種由cAMP激活的絲氨酸/蘇氨酸蛋白激酶,由兩個(gè)催化亞基和兩個(gè)調(diào)節(jié)亞基組成。在沒有cAMP時(shí),PKA以鈍化復(fù)合體形式存在。cAMP與調(diào)節(jié)亞基結(jié)合后,導(dǎo)致調(diào)節(jié)亞基構(gòu)象變化,使調(diào)節(jié)亞基和催化亞基解離,釋放出催化亞基,進(jìn)而使細(xì)胞內(nèi)某些蛋白的絲氨酸或蘇氨酸殘基磷酸化,改變這些蛋白的活性,影響相關(guān)基因的表達(dá)。PRKACA參與調(diào)節(jié)多種細(xì)胞功能,包括糖原、糖和脂質(zhì)的代謝,以及晝夜睡眠/覺醒周期、快速眼動(dòng)睡眠等生理過程。PRKACA的異常活性與多種疾病相關(guān),如腎上腺皮質(zhì)腺瘤、充血性心力衰竭和原發(fā)性色素性結(jié)節(jié)性腎上腺皮質(zhì)疾病。

熱銷產(chǎn)品

Recombinant Human cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) (CSB-EP018688HU)

驗(yàn)證數(shù)據(jù)

CSB-EP018688HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PRKACA Antibody (CSB-PA018688LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA018688LA01HU

Western Blot
Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, A549 whole cell lysate
All lanes: PRKACA antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 41, 40 kDa
Observed band size: 41 kDa

CSB-PA018688LA01HU

IHC image of CSB-PA018688LA01HU diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA018688LA01HU

IHC image of CSB-PA018688LA01HU diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

PRKACA Antibodies

PRKACA for Homo sapiens (Human)

PRKACA Proteins

PRKACA Proteins for Homo sapiens (Human)

PRKACA Proteins for Rattus norvegicus (Rat)

PRKACA Proteins for Sus scrofa (Pig)

PRKACA Proteins for Mus musculus (Mouse)

PRKACA Proteins for Bos taurus (Bovine)

PRKACA Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

PRKACA Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

PRKACA Proteins for Ovis aries (Sheep)

PRKACA Proteins for Canis lupus familiaris (Dog) (Canis familiaris)