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PLAUR

尿激酶型纖溶酶原激活物受體(PLAUR,又稱uPAR或CD87)是一種錨定于細(xì)胞膜表面的糖蛋白受體,其核心功能是通過(guò)與尿激酶(uPA)結(jié)合,激活纖溶酶原轉(zhuǎn)化為纖溶酶,進(jìn)而觸發(fā)細(xì)胞外基質(zhì)降解酶類的級(jí)聯(lián)反應(yīng)。這一過(guò)程在組織重塑、傷口愈合中起關(guān)鍵作用,但也被發(fā)現(xiàn)與惡性腫瘤的侵襲轉(zhuǎn)移密切相關(guān)。臨床研究顯示,PLAUR在乳腺癌、結(jié)直腸癌等多種實(shí)體瘤中高表達(dá),其水平升高常提示患者預(yù)后不良。該受體還能與整合素等跨膜蛋白協(xié)同調(diào)控細(xì)胞遷移,參與動(dòng)脈粥樣硬化斑塊形成及類風(fēng)濕性關(guān)節(jié)炎的病理進(jìn)程。
近年來(lái)針對(duì)PLAUR的藥物開發(fā)聚焦于阻斷uPA-uPAR相互作用,例如單抗類藥物ATN-658已在動(dòng)物模型中顯著抑制腫瘤轉(zhuǎn)移。小分子抑制劑如upain-1通過(guò)干擾受體二聚化降低癌細(xì)胞侵襲能力,目前處于臨床前研究階段。部分聯(lián)合治療方案嘗試將uPAR靶向藥物與傳統(tǒng)化療聯(lián)用,初步數(shù)據(jù)顯示可增強(qiáng)抗腫瘤效果并減少耐藥性,但尚未進(jìn)入三期臨床試驗(yàn)。

熱銷產(chǎn)品

Recombinant Human Urokinase plasminogen activator surface receptor (PLAUR) (CSB-EP018122HU)

驗(yàn)證數(shù)據(jù)

CSB-EP018122HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PLAUR Recombinant Monoclonal Antibody (CSB-RA018122MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA018122MA1HU

Immunofluorescence staining of hela cell with CSB-RA018122MA1HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).

CSB-RA018122MA1HU

Immunofluorescence staining of SH-SY5Y cell with CSB-RA018122MA1HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).

CSB-RA018122MA1HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA018122MA1HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,026 events was performed.

PLAUR Antibodies

PLAUR for Rattus norvegicus (Rat)

PLAUR for Homo sapiens (Human)

PLAUR Proteins

PLAUR Proteins for Homo sapiens (Human)

PLAUR Proteins for Mus musculus (Mouse)

PLAUR Proteins for Rattus norvegicus (Rat)

PLAUR Proteins for Bos taurus (Bovine)

PLAUR Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

PLAUR Proteins for Aotus trivirgatus (Night monkey) (Douroucouli)

PLAUR Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

PLAUR Proteins for Pan troglodytes (Chimpanzee)

PLAUR ELISA Kit

PLAUR ELISA Kit for Homo sapiens (Human)

PLAUR ELISA Kit for Rattus norvegicus (Rat)