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NES

NES,全名為核輸出序列蛋白,也被稱為核輸出序列。該蛋白在細胞核與細胞質之間的蛋白質運輸中發(fā)揮關鍵作用。NES蛋白通過識別并結合特定的核定位信號,將蛋白質從細胞核通過核孔復合體運輸?shù)郊毎|。這一過程對于維持細胞內蛋白質平衡和細胞功能至關重要。NES蛋白的異常與多種疾病相關,包括腫瘤、神經(jīng)退行性疾病等。在藥物研發(fā)方面,針對NES蛋白的藥物正在研發(fā)中,旨在治療與NES蛋白功能異常相關的疾病。

熱銷產品

Recombinant Human Nestin (NES), partial (CSB-YP015713HU)

驗證數(shù)據(jù)

CSB-YP015713HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

NES Monoclonal Antibody (CSB-MA0157131A0m)

驗證數(shù)據(jù)

CSB-MA0157131A0m

Western Blot
Positive WB detected in: U251 whole cell lysate, SH-SY5Y whole cell lysate
All lanes: NES antibody at 3µg/ml
Secondary
Goat polyclonal to Mouse IgG at 1/10000 dilution
Predicted band size: 178 kDa
Observed band size: 260 kDa

CSB-MA0157131A0m

Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-MA0157131A0m at dilution of 1:100

CSB-MA0157131A0m

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-MA0157131A0m at dilution of 1:100

CSB-MA0157131A0m

Immunohistochemistry of paraffin-embedded human melanoma using CSB-MA0157131A0m at dilution of 1:100

CSB-MA0157131A0m

Immunofluorescent analysis of Hela cells using CSB-MA0157131A0m at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Mouse IgG(H+L).

CSB-MA0157131A0m

Immunofluorescent analysis of PC-3 cells using CSB-MA0157131A0m at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Mouse IgG(H+L).

CSB-MA0157131A0m

Immunofluorescent analysis of U251 cells using CSB-MA0157131A0m at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Mouse IgG(H+L).

CSB-MA0157131A0m

Overlay histogram showing U251 cells stained with CSB-MA0157131A0m (red line). The cells were fixed with 70% Ethylalcohol (18h) and then permeabilized with 0.3% Triton X-100 for 2 min. The cells were then incubated in 1x PBS /10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (10µg/1*106cells) for 1 h at 4°C. The secondary antibody used was FITC goat anti-mouse IgG(H+L) at 1/200 dilution for 1 h at 4°C. Isotype control antibody (green line) was mouse IgG1 (10µg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

CSB-MA0157131A0m

Overlay histogram showing Hela cells stained with CSB-MA0157131A0m (red line). The cells were fixed with 70% Ethylalcohol (18h) and then permeabilized with 0.3% Triton X-100 for 2 min. The cells were then incubated in 1x PBS /10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (10µg/1*106cells) for 1 h at 4°C. The secondary antibody used was FITC goat anti-mouse IgG(H+L) at 1/200 dilution for 1 h at 4°C. Isotype control antibody (green line) was mouse IgG1 (10µg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

NES Antibodies

NES for Homo sapiens (Human)

NES Proteins

NES Proteins for Rattus norvegicus (Rat)

NES Proteins for Homo sapiens (Human)

NES Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

NES Proteins for Mus musculus (Mouse)

NES Proteins for Mesocricetus auratus (Golden hamster)

NES Proteins for Drosophila melanogaster (Fruit fly)