ITGAM

ITGAM，全稱為整合素αM鏈，是一種重要的細胞表面受體，參與多種細胞間相互作用和信號傳導(dǎo)過程。它常見別名包括MAC-1和CD11b，在免疫細胞，如巨噬細胞、中性粒細胞和NK細胞中高度表達。ITGAM與β2鏈（ITGB2）結(jié)合形成αMβ2整合素（Mac-1），能夠識別并結(jié)合多種配體，包括ICAM-1、C3bi、纖維蛋白原和纖維連接蛋白等。這種受體在細胞粘附、遷移、吞噬和信號傳導(dǎo)中發(fā)揮著關(guān)鍵作用。
Mac-1參與多種生理和病理過程，如免疫應(yīng)答、炎癥反應(yīng)和傷口愈合。它還在腫瘤細胞的增殖、轉(zhuǎn)移和耐藥性中發(fā)揮作用。因此，Mac-1成為免疫治療和抗腫瘤藥物研發(fā)的重要靶點。目前，針對Mac-1的藥物研發(fā)主要集中在抗體藥物和免疫檢查點抑制劑等方面。例如，抗Mac-1抗體可用于靶向清除巨噬細胞，從而抑制腫瘤生長和轉(zhuǎn)移；免疫檢查點抑制劑可與Mac-1結(jié)合，阻斷其與配體的結(jié)合，從而抑制腫瘤細胞的免疫逃逸。

熱銷產(chǎn)品

Recombinant Human Integrin alpha-M (ITGAM), partial (CSB-EP011876HU)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ITGAM Recombinant Monoclonal Antibody (CSB-RA067983A0HU)

驗證數(shù)據(jù)

Western Blot
Positive WB detected in:A549 whole cell lysate(30μg)
All lanes: CD11b antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/40000 dilution
Predicted band size: 127 kDa
Observed band size: 127 kDa
Exposure time：3min

Human Integrin αM,ITG/CD11b ELISA Kit (CSB-E11638h)

驗證數(shù)據(jù)

貨號：CSB-E11638h

規(guī)格：96T/48T

靈敏度：0.195 ng/mL

檢測范圍：0.78 ng/mL-50 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ITGAM Antibody

ITGAM Protein

ITGAM ELISA Kit

ITGAM Antibodies

ITGAM for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA148981	ITGAM Antibody	Human	ELISA,IHC
CSB-PA073350	ITGAM Antibody	Human	ELISA,IHC
CSB-PA011876LA01HU	ITGAM Antibody	Human	ELISA, IHC, IF
CSB-PA011876LB01HU	ITGAM Antibody, HRP conjugated	Human	ELISA
CSB-PA011876LC01HU	ITGAM Antibody, FITC conjugated	Human
CSB-PA011876LD01HU	ITGAM Antibody, Biotin conjugated	Human	ELISA
CSB-RA067983A0HU	ITGAM Recombinant Monoclonal Antibody	Human	ELISA, WB

ITGAM Proteins

ITGAM Proteins for Cavia porcellus (Guinea pig)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP011876GU CSB-EP011876GU CSB-BP011876GU CSB-MP011876GU CSB-EP011876GU-B	Recombinant Guinea pig Integrin alpha-M (ITGAM)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ITGAM Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP011876HU CSB-BP011876HU CSB-MP011876HU CSB-EP011876HU-B	Recombinant Human Integrin alpha-M (ITGAM), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP011876HU	Recombinant Human Integrin alpha-M (ITGAM), partial	E.coli

ITGAM Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP011876MO CSB-EP011876MO CSB-BP011876MO CSB-MP011876MO CSB-EP011876MO-B	Recombinant Mouse Integrin alpha-M (Itgam), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli