IL1A
IL1A，即白細(xì)胞介素1α，別名IL-1α、Hematopoietin-1、Lymphocyte-Activating Factor (LAF)、Endogenous Pyrogen (EP)、IL1F1等。它是一種由IL1A基因編碼的多效性細(xì)胞因子，主要由活化的巨噬細(xì)胞、中性粒細(xì)胞、上皮細(xì)胞和內(nèi)皮細(xì)胞產(chǎn)生 。IL1A的作用機制涉及其前體蛋白在細(xì)胞內(nèi)的轉(zhuǎn)錄因子功能以及成熟形式在細(xì)胞外的信號傳導(dǎo)作用。IL1A前體在細(xì)胞核內(nèi)促進(jìn)基因表達(dá)，調(diào)控細(xì)胞生長和分化。成熟形式的IL1A通過與細(xì)胞表面的IL-1受體IL1R1結(jié)合，觸發(fā)信號傳導(dǎo)復(fù)合物的形成，激活NF-kappa-B和MAPK通路，從而引發(fā)炎癥反應(yīng)和免疫應(yīng)答 。在生物學(xué)意義上，IL1A在機體的炎癥反應(yīng)、免疫調(diào)節(jié)以及與多種疾病的關(guān)聯(lián)中發(fā)揮關(guān)鍵作用。它參與機體抗微生物感染、無菌炎癥、腫瘤相關(guān)疾病以及自發(fā)炎癥的調(diào)節(jié)。IL1A的異常表達(dá)與多種疾病有關(guān)，包括Fabry病、Schnitzler綜合征、多種自身免疫性疾病、血液腫瘤和肺部疾病等。因此，IL1A是炎癥和免疫相關(guān)疾病研究中的一個重要分子靶點，并且是臨床治療多種疾病的潛在標(biāo)志物和治療靶點 。
熱銷產(chǎn)品
Recombinant Human Interleukin-1 alpha (IL1A) (CSB-YP011613HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA584603(IL1A Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA584603(IL1A Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cells, Primary antibody: CSB-PA584603(IL1A Antibody) at dilution 1/666, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
Human Interleukin 1α,IL-1α ELISA Kit (CSB-E04620h)
驗證數(shù)據(jù)
貨號：CSB-E04620h
規(guī)格：96T/48T
靈敏度：0.975 pg/ml.
檢測范圍：3.9 pg/ml-250 pg/ml.
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
IL1A Antibodies
IL1A for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA06565A0Rb | IL1A Antibody | Human | ELISA |
| CSB-PA06565C0Rb | IL1A Antibody, FITC conjugated | Human | |
| CSB-PA011613GA01HU | IL1A Antibody | Human | ELISA,WB |
| CSB-PA009537 | IL1A Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA107052 | IL1A Antibody | Human | ELISA,IHC |
| CSB-PA584603 | IL1A Antibody | Human | ELISA,WB,IHC |
IL1A for Macaca mulatta
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA011613LA01MOW | IL1A Antibody | Macaca mulatta, Human | ELISA, WB |
IL1A Proteins
IL1A Proteins for Capra hircus (Goat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011613GO CSB-EP011613GO CSB-BP011613GO CSB-MP011613GO CSB-EP011613GO-B |
Recombinant Goat Interleukin-1 alpha (IL1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011613PI CSB-EP011613PI CSB-BP011613PI CSB-MP011613PI CSB-EP011613PI-B |
Recombinant Pig Interleukin-1 alpha (IL1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011613MOW | Recombinant Macaca mulatta Interleukin-1 alpha (IL1A) | Yeast |
| CSB-AP003071MOW | Recombinant Macaca mulatta Interleukin-1 alpha (IL1A) (Active) | E.Coli |
| CSB-EP011613MOW | Recombinant Macaca mulatta Interleukin-1 alpha (IL1A) | E.coli |
| CSB-BP011613MOW CSB-MP011613MOW CSB-EP011613MOW-B |
Recombinant Macaca mulatta Interleukin-1 alpha (IL1A) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011613MO CSB-EP011613MO CSB-BP011613MO CSB-MP011613MO CSB-EP011613MO-B |
Recombinant Mouse Interleukin-1 alpha (Il1a) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP003251MO | Recombinant Mouse Interleukin-1 alpha protein (Il1a) | E.Coli |
| CSB-AP004721MO | Recombinant Mouse Interleukin-1 alpha (Il1a) (Active) | E.coli |
IL1A Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011613HU | Recombinant Human Interleukin-1 alpha (IL1A) | Yeast |
| CSB-EP011613HUe0 | Recombinant Human Interleukin-1 alpha (IL1A) | E.coli |
| CSB-EP011613HU | Recombinant Human Interleukin-1 alpha (IL1A) | E.coli |
| CSB-AP001661HU | Recombinant Human Interleukin-1 alpha protein (IL1A) | E.Coli |
| CSB-BP011613HU CSB-MP011613HU |
Recombinant Human Interleukin-1 alpha (IL1A) | Baculovirus Mammalian cell |
| CSB-YP011613HUc7 | Recombinant Human Interleukin-1 alpha (IL1A) | Yeast |
| CSB-AP004261HU | Recombinant Human Interleukin-1 alpha (IL1A) (Active) | E.coli |
| CSB-AP005801HU | Recombinant Human Interleukin-1 alpha (IL1A) (Active) (GMP) | E.Coli |
| CSB-EP011613HU-B | Recombinant Human Interleukin-1 alpha (IL1A),Biotinylated | E.coli |
IL1A Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011613BO CSB-EP011613BO CSB-BP011613BO CSB-MP011613BO CSB-EP011613BO-B |
Recombinant Bovine Interleukin-1 alpha (IL1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011613RB CSB-EP011613RB CSB-BP011613RB CSB-MP011613RB CSB-EP011613RB-B |
Recombinant Rabbit Interleukin-1 alpha (IL1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011613CA CSB-EP011613CA CSB-BP011613CA CSB-MP011613CA CSB-EP011613CA-B |
Recombinant Cat Interleukin-1 alpha (IL1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011613DO CSB-EP011613DO CSB-BP011613DO CSB-MP011613DO CSB-EP011613DO-B |
Recombinant Dog Interleukin-1 alpha (IL1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-BP011613MOV CSB-MP011613MOV CSB-EP011613MOV-B |
Recombinant Macaca fascicularis Interleukin-1 alpha (IL1A) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011613RA CSB-EP011613RA CSB-BP011613RA CSB-MP011613RA CSB-EP011613RA-B |
Recombinant Rat Interleukin-1 alpha (Il1a) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011613DRI CSB-EP011613DRI CSB-BP011613DRI CSB-MP011613DRI CSB-EP011613DRI-B |
Recombinant Cercocebus atys Interleukin-1 alpha (IL1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Ovis aries (Sheep)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP630687SH CSB-EP630687SH CSB-BP630687SH CSB-MP630687SH CSB-EP630687SH-B |
Recombinant Sheep Interleukin-1 alpha (IL1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Equus caballus (Horse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP636720HO CSB-EP636720HO CSB-BP636720HO CSB-MP636720HO CSB-EP636720HO-B |
Recombinant Horse Interleukin-1 alpha (IL1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Bubalus carabanensis (Swamp type water buffalo) (Bubalus bubalis carabanensis)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP661675BAAW CSB-EP661675BAAW CSB-BP661675BAAW CSB-MP661675BAAW CSB-EP661675BAAW-B |
Recombinant Bubalus carabanensis Interleukin-1 alpha (IL1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Cavia porcellus (Guinea pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP733672GU CSB-EP733672GU CSB-BP733672GU CSB-MP733672GU CSB-EP733672GU-B |
Recombinant Guinea pig Interleukin-1 alpha (IL1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Lama glama (Llama)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP774725LBS CSB-EP774725LBS CSB-BP774725LBS CSB-MP774725LBS CSB-EP774725LBS-B |
Recombinant Lama glama Interleukin-1 alpha (IL1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A ELISA Kit
IL1A ELISA Kit for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E12019B | Bovine Interleukin 1,IL-1 ELISA Kit | serum, plasma, tissue homogenates | 250 pg/mL |
IL1A ELISA Kit for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E06896Rb | Rabbit Interleukin 1,IL-1 ELISA Kit | serum, plasma, tissue homogenates | 3.9 pg/mL |
IL1A ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04620h | Human Interleukin 1α,IL-1α ELISA Kit | serum, plasma, tissue homogenates, cell lysates, cell culture supernates. | 0.975 pg/ml. |
IL1A ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04621m | Mouse Interleukin 1α,IL-1α ELISA kit | serum, plasma, tissue homogenates | 0.58 pg/ml |
IL1A ELISA Kit for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09725p | Pig Interleukin 1α,IL-1α ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 6.25 pg/mL |
IL1A ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04622r | Rat Interleukin 1α,IL-1α ELISA kit | serum, plasma, tissue homogenates. | 19.5 pg/ml. |
IL1A ELISA Kit for Monkey
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E10041Mo | Monkey Interleukin-1 alpha (IL1A) ELISA kit | serum, plasma, tissue homogenates | 1.95 pg/mL |
