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GZMB

GZMB,即顆粒酶B,別名CCPI、CGL-1、CSP-B、CGL1、CTSGL1、HLP、SECT。GZMB是一種由細(xì)胞毒性T細(xì)胞(CTLs)和自然殺傷細(xì)胞(NK細(xì)胞)產(chǎn)生的絲氨酸蛋白酶,屬于細(xì)胞毒性淋巴細(xì)胞顆粒中的酶類。GZMB的作用機(jī)制包括其在細(xì)胞外環(huán)境中的作用,如導(dǎo)致炎癥、血管功能障礙和通透性、細(xì)胞粘附減少、基質(zhì)隔離生長(zhǎng)因子的釋放、受體激活和細(xì)胞外基質(zhì)裂解。GZMB在多種病理狀態(tài)下發(fā)揮作用,包括心血管疾病、自身免疫性疾病、腫瘤免疫逃逸等。GZMB不僅參與細(xì)胞凋亡過(guò)程,還與炎癥反應(yīng)、組織重塑和腫瘤免疫監(jiān)視有關(guān)。GZMB的活性受到嚴(yán)格調(diào)控,其異常表達(dá)與多種疾病的發(fā)生發(fā)展相關(guān),是一個(gè)有潛力的治療靶點(diǎn)和生物標(biāo)志物。

熱銷產(chǎn)品

Recombinant Human Granzyme B (GZMB) (CSB-EP010082HU)

驗(yàn)證數(shù)據(jù)

CSB-EP010082HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

GZMB Recombinant Monoclonal Antibody (CSB-RA010082MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA010082MA1HU

Western Blot Positive WB detected in:K562 whole cell lysate (20μg) All lanes: GZMB antibody at 1:1000 Secondary Goat polyclonal to mouse IgG at 1/50000 dilution Predicted band size:27.7 kDa Observed band size:28 kDa Exposure time:300s

CSB-RA010082MA1HU

IHC?image?of?CSB-RA010082MA1HU?diluted?at?1:50?and?staining?in?paraffin-embedded?human?tonsil tissue?performed?on?a?Leica?BondTM?system.?After?dewaxing?and?hydration,?antigen?retrieval?was?mediated?by?high?pressure?in?a?citrate?buffer?(pH?6.0).?Section?was?blocked?with?10%?normal?goat?serum?30min?at?RT.?Then?primary?antibody?(1%?BSA)?was?incubated?at?4°C?overnight.?The?primary?is?detected?by?a?Goat?anti-Mouse?IgG?labeled?by?HRP?and?visualized?using?0.05%?DAB.

CSB-RA010082MA1HU

Overlay Peak curve showing THP-1 cells stained with CSB-RA010082MA1HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was mouse IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

GZMB Antibodies

GZMB for Homo sapiens (Human)

GZMB Proteins

GZMB Proteins for Homo sapiens (Human)

GZMB Proteins for Rattus norvegicus (Rat)

GZMB Proteins for Mus musculus (Mouse)

GZMB ELISA Kit

GZMB ELISA Kit for Homo sapiens (Human)

GZMB ELISA Kit for Mus musculus (Mouse)