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FOXA1

FOXA1,即叉頭框蛋白A1,別名HNF3α。FOXA1是一種在多個生物學(xué)過程中起核心作用的轉(zhuǎn)錄因子,包括器官發(fā)生、分化、糖脂代謝、細(xì)胞增殖、遷移和侵襲,以及藥物抗性。FOXA1通過結(jié)合到基因組上的特定區(qū)域,幫助打開染色質(zhì)結(jié)構(gòu),從而作為先鋒因子促進(jìn)其他轉(zhuǎn)錄因子的結(jié)合和基因的轉(zhuǎn)錄。在癌癥中,F(xiàn)OXA1與激素受體如雌激素受體ER和雄激素受體AR等相互作用,調(diào)控相關(guān)癌癥的發(fā)生、發(fā)展、轉(zhuǎn)移、耐藥等過程。FOXA1的突變或表觀遺傳修飾與多種癌癥的發(fā)展和治療抗性相關(guān),尤其是在雌激素受體陽性的乳腺癌和前列腺癌中。FOXA1還參與調(diào)節(jié)多種代謝途徑,包括糖代謝和脂代謝,影響細(xì)胞的代謝狀態(tài)和能量平衡。因此,F(xiàn)OXA1在維持細(xì)胞正常功能和促進(jìn)疾病進(jìn)展中扮演著關(guān)鍵角色,是癌癥治療中的一個重要靶點。

熱銷產(chǎn)品

Recombinant Human Hepatocyte nuclear factor 3-alpha (FOXA1) (CSB-EP008794HU)

驗證數(shù)據(jù)

CSB-EP008794HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

FOXA1 Recombinant Monoclonal Antibody (CSB-RA246102A0HU)

驗證數(shù)據(jù)

CSB-RA246102A0HU

Western Blot
Positive WB detected in: MCF-7 whole cell lysate, HepG2 whole cell lysate, PC-3 whole cell lysate, 293 whole cell lysate, Hela whole cell lysate
All lanes: FOXA1 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 50, 46 kDa
Observed band size: 50 kDa

CSB-RA246102A0HU

IHC image of CSB-RA246102A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA246102A0HU

IHC image of CSB-RA246102A0HU diluted at 1:100 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA246102A0HU

Immunoprecipitating FOXA1 in Hela whole cell lysate
Lane 1: Rabbit control IgG instead of CSB-RA246102A0HU in Hela whole cell lysate. For western blotting,a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-RA246102A0HU(2μg)+ Hela whole cell lysate(500μg)
Lane 3: Hela whole cell lysate (10μg)

FOXA1 Antibodies

FOXA1 for Homo sapiens (Human)

FOXA1 Proteins

FOXA1 Proteins for Mus musculus (Mouse)

FOXA1 Proteins for Rattus norvegicus (Rat)

FOXA1 Proteins for Homo sapiens (Human)

FOXA1 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)