FCGR1A
FCGR1A全稱為高親和力免疫球蛋白γ Fc受體I（FcγRI），又名CD64，是免疫系統(tǒng)中重要的調(diào)控分子。FCGR1A主要表達(dá)于單核細(xì)胞、巨噬細(xì)胞等髓系細(xì)胞表面，通過與IgG抗體的Fc段結(jié)合，觸發(fā)吞噬、炎癥因子釋放等免疫應(yīng)答，在抗感染和清除病原體中起關(guān)鍵作用。FcγRI的異?；罨c類風(fēng)濕性關(guān)節(jié)炎、系統(tǒng)性紅斑狼瘡等自身免疫疾病密切相關(guān)，其過度激活可能導(dǎo)致組織損傷。在感染領(lǐng)域，該受體參與膿毒癥等重癥炎癥反應(yīng)的發(fā)展過程。近年來針對FcγRI的藥物開發(fā)聚焦于單克隆抗體和小分子抑制劑，已有候選藥物進(jìn)入I期臨床試驗(yàn)，用于治療慢性蕁麻疹和特應(yīng)性皮炎。部分研究嘗試通過阻斷FcγRI信號減輕自身免疫反應(yīng)，同時(shí)探索其與PD-1抑制劑聯(lián)用增強(qiáng)腫瘤免疫治療效果的可能性。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
FCGR1A Antibody (CSB-PA936888)
驗(yàn)證數(shù)據(jù)
Western blot analysis of mouse-kidney lysate, antibody was diluted at 2000. Secondary antibody was diluted at 1:20000
Immunohistochemical analysis of paraffin-embedded human-stomach-cancer, antibody was diluted at 1:200
Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200
Human High affinity immunoglobulin gamma Fc receptor I(FCGR1A) ELISA kit (CSB-EL008537HU)
驗(yàn)證數(shù)據(jù)
貨號：CSB-EL008537HU
規(guī)格：96T/48T
靈敏度：0.2 ng/mL
檢測范圍：0.78 ng/mL-50 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
FCGR1A Antibodies
FCGR1A for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA936888 | FCGR1A Antibody | Human | WB, IHC, ELISA |
FCGR1A Proteins
FCGR1A Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP008537HU1 CSB-BP008537HU1 CSB-MP008537HU1 CSB-EP008537HU1-B |
Recombinant Human High affinity immunoglobulin gamma Fc receptor I (FCGR1A), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF008537HU | Recombinant Human High affinity immunoglobulin gamma Fc receptor I (FCGR1A) | in vitro E.coli expression system |
| CSB-EP008537HU1 | Recombinant Human High affinity immunoglobulin gamma Fc receptor I (FCGR1A), partial | E.coli |
| CSB-MP008537HU | Recombinant Human High affinity immunoglobulin gamma Fc receptor I (FCGR1A)-VLPs | Mammalian cell |
FCGR1A ELISA Kit
FCGR1A ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL008537HU | Human High affinity immunoglobulin gamma Fc receptor I(FCGR1A) ELISA kit | serum, plasma, tissue homogenates | 0.2 ng/mL |
