CFD

補體因子D（Complement Factor D，CFD）又稱脂肪細胞特異性分泌因子Adipsin，是補體系統(tǒng)旁路途徑的核心蛋白酶。CFD由脂肪細胞及肝臟合成，在血液中以低濃度持續(xù)存在，通過特異性切割補體因子B激活補體級聯(lián)反應(yīng)，形成C3轉(zhuǎn)化酶放大炎癥信號。CFD異常表達與年齡相關(guān)性黃斑變性密切相關(guān)，其過度激活會導(dǎo)致視網(wǎng)膜色素上皮細胞損傷，全球約15%的AMD患者存在CFD基因變異。在代謝性疾病領(lǐng)域，CFD水平升高可加劇胰島素抵抗，與2型糖尿病腎病進展呈正相關(guān)。目前針對CFD的單克隆抗體藥物APL-2已完成二期臨床試驗，通過抑制補體旁路途徑顯著降低地理萎縮患者的病灶擴大速度。CFD抑制劑還被探索用于陣發(fā)性睡眠性血紅蛋白尿癥和IgA腎病的治療，已有小分子化合物進入臨床前研究階段。

熱銷產(chǎn)品

CFD Antibody (CSB-PA005271ESR2HU)

驗證數(shù)據(jù)

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA005271ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA005271ESR2HU at dilution of 1:100

CFD Antibody

CFD Protein

CFD ELISA Kit

CFD Antibodies

CFD for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA005271ESR2HU	CFD Antibody	Human	ELISA, IHC

CFD Proteins

CFD Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP005271RA	Recombinant Rat Complement factor D (Cfd)	Yeast
CSB-EP005271RA	Recombinant Rat Complement factor D (Cfd)	E.coli
CSB-BP005271RA CSB-EP005271RA-B	Recombinant Rat Complement factor D (Cfd)	Baculovirus In Vivo Biotinylation in E.coli
CSB-MP005271RA	Recombinant Rat Complement factor D (Cfd)	Mammalian cell
CSB-MP005271RAd9	Recombinant Rat Complement factor D (Cfd)	Mammalian cell

CFD Proteins for Sus scrofa (Pig)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP005271PI CSB-EP005271PI CSB-BP005271PI CSB-MP005271PI CSB-EP005271PI-B	Recombinant Pig Complement factor D (CFD)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFD Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP005271HU CSB-EP005271HU CSB-BP005271HU CSB-MP005271HU CSB-EP005271HU-B	Recombinant Human Complement factor D (CFD)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFD Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP005271MO CSB-EP005271MO CSB-BP005271MO CSB-MP005271MO CSB-EP005271MO-B	Recombinant Mouse Complement factor D (Cfd)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CFD Proteins for Bos taurus (Bovine)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP660982BO CSB-EP660982BO CSB-BP660982BO CSB-MP660982BO CSB-EP660982BO-B	Recombinant Bovine Complement factor D (CFD)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli