CDH5
CDH5，即血管內皮鈣粘蛋白，別名VE-cadherin/Cadherin-5。它是一種由CDH5基因編碼的II型經典鈣粘蛋白家族成員，主要在血管內皮細胞中表達。CDH5的作用機制涉及介導內皮細胞間的同質性粘附，通過其細胞外結構域與相鄰細胞的CDH5分子相互作用，形成穩(wěn)定的粘附連接。這種粘附對于維持血管完整性和調節(jié)血管通透性至關重要。此外，CDH5與α-連環(huán)蛋白結合，形成與細胞骨架的連接，參與調控內皮細胞的極性和血管腔的形成。CDH5的功能還涉及到與KRIT1和PAR-1等蛋白的相互作用，共同維持內皮細胞的穩(wěn)定性和功能。CDH5在生物學上的意義主要體現在其對血管內皮細胞生物學的調控作用。它參與了多種生理過程，包括血管新生、血管穩(wěn)定和炎癥反應。在腫瘤發(fā)生發(fā)展過程中，CDH5的表達水平和功能異常與腫瘤血管生成、腫瘤細胞的侵襲和轉移密切相關。此外，CDH5還參與了內皮細胞的屏障功能和細胞信號傳導，影響細胞增殖、遷移和分化。因此，CDH5是血管相關疾病研究和治療中的一個重要靶點，例如在抗血管生成治療和腫瘤治療中具有潛在的應用價值。
熱銷產品
CDH5 Antibody (CSB-PA07519A0Rb)
驗證數據
Western Blot
Positive WB detected in: Mouse lung tissue, Mouse kidney tissue
All lanes: CDH5 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 88, 75 kDa
Observed band size: 88 kDa
Immunofluorescent analysis of HepG2 cells using CSB-PA07519A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Mouse Cadherin-5(CDH5) ELISA kit (CSB-EL005054MO)
驗證數據
貨號：CSB-EL005054MO
規(guī)格：96T/48T
靈敏度：0.058 ng/mL
檢測范圍：0.235 ng/mL-15 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
CDH5 Antibodies
CDH5 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA868788 | Phospho-CDH5 (Tyr731) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA006270 | CDH5 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA006366 | Phospho-CDH5 (Y731) Antibody | Human,Mouse | WB, IHC, ELISA |
| CSB-PA006367 | CDH5 Antibody | Human,Mouse | WB, IHC, ELISA |
| CSB-PA947781 | CDH5 Antibody | Human | ELISA,IHC |
| CSB-PA102499 | CDH5 Antibody | Human | ELISA,IHC |
| CSB-PA440133 | CDH5 Antibody | Human | ELISA,IHC |
| CSB-PA07519A0Rb | CDH5 Antibody | Human, Mouse | ELISA, WB, IF |
| CSB-PA07519C0Rb | CDH5 Antibody, FITC conjugated | Human | |
| CSB-PA07519D0Rb | CDH5 Antibody, Biotin conjugated | Human | ELISA |
| CSB-MA249655 | CDH5 Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-MA554141 | CDH5 Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
CDH5 Proteins
CDH5 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP005054HU1 CSB-EP005054HU1 CSB-BP005054HU1 CSB-EP005054HU1-B |
Recombinant Human Cadherin-5 (CDH5), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF005054HU | Recombinant Human Cadherin-5 (CDH5) | in vitro E.coli expression system |
| CSB-MP005054HU1 | Recombinant Human Cadherin-5 (CDH5), Partial | Mammalian cell |
CDH5 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP005054MO1 CSB-EP005054MO1 CSB-BP005054MO1 CSB-MP005054MO1 CSB-EP005054MO1-B |
Recombinant Mouse Cadherin-5 (Cdh5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF005054MO | Recombinant Mouse Cadherin-5 (Cdh5) | in vitro E.coli expression system |
CDH5 Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP005054PI1 CSB-EP005054PI1 CSB-BP005054PI1 CSB-MP005054PI1 CSB-EP005054PI1-B |
Recombinant Pig Cadherin-5 (CDH5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF005054PI | Recombinant Pig Cadherin-5 (CDH5) | in vitro E.coli expression system |
CDH5 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP764929BO CSB-EP764929BO CSB-BP764929BO CSB-MP764929BO CSB-EP764929BO-B |
Recombinant Bovine Cadherin-5 (CDH5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CDH5 ELISA Kit
CDH5 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09372h | Human Vascular Endothelial-Cadherin,VE-cad ELISA Kit | serum, plasma, tissue homogenates | 0.98 ng/mL |
CDH5 ELISA Kit for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL005054MO | Mouse Cadherin-5(CDH5) ELISA kit | serum, plasma, tissue homogenates | 0.058 ng/mL |
