CD59

CD59，即補(bǔ)體膜攻擊復(fù)合物抑制因子，別名MAC-IP、MACIF、MEM43等。這是一種糖基磷脂酰肌醇錨定的糖蛋白，由CD59基因編碼，廣泛分布于人體多種細(xì)胞表面，包括紅細(xì)胞、白細(xì)胞、內(nèi)皮細(xì)胞和神經(jīng)元等。CD59的主要作用是在補(bǔ)體系統(tǒng)激活的最后階段，通過干擾C8和C9的結(jié)合，抑制膜攻擊復(fù)合物（MAC）的形成，從而保護(hù)宿主細(xì)胞免受補(bǔ)體介導(dǎo)的溶解。這一作用對于防止自身免疫性疾病的發(fā)生至關(guān)重要。CD59的異常表達(dá)與多種疾病相關(guān)，包括陣發(fā)性睡眠性血紅蛋白尿（PNH）、某些癌癥、自身免疫性疾病如糖尿病和多發(fā)性硬化等。在腫瘤細(xì)胞中，CD59的高表達(dá)可能與對抗單克隆抗體治療的耐藥性有關(guān)。此外，CD59還參與調(diào)節(jié)T細(xì)胞的粘附和激活，以及在神經(jīng)系統(tǒng)中可能發(fā)揮某些作用。因此，CD59不僅在維持免疫系統(tǒng)平衡中起著關(guān)鍵作用，也可能成為未來治療某些疾病的潛在靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human CD59 glycoprotein (CD59) (CSB-YP004947HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CD59 Recombinant Monoclonal Antibody (CSB-RA046065A0HU)

驗(yàn)證數(shù)據(jù)

Overlay Peak curve showing Hela cells surface stained with CSB-RA046065A0HU (red line) at 1:50. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*10⁶cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*10⁶cells) used under the same conditions. Acquisition of >10,000 events was performed.

CD59 Antibody

CD59 Protein

CD59 ELISA Kit

CD59 Antibodies

CD59 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA004947GA01HU	CD59 Antibody	Human	ELISA,WB,IHC
CSB-PA004947ED01HU	CD59 Antibody, Biotin conjugated	Human	ELISA
CSB-PA004947YA01HU	CD59 Antibody	Human, Mouse	ELISA, WB, IHC, IF
CSB-PA004947EA01HU	CD59 Antibody	Human	ELISA, IHC, IF
CSB-PA004947YB01HU	CD59 Antibody, HRP conjugated	Human	ELISA
CSB-PA005228	CD59 Antibody	Human	WB, ELISA
CSB-MA0049471A0m	CD59 Monoclonal Antibody	Human	ELISA,WB,IHC
CSB-PA778176	CD59 Antibody	Human	ELISA,WB,IHC
CSB-PA569443	CD59 Antibody	Human	ELISA,IHC
CSB-RA046065A0HU	CD59 Recombinant Monoclonal Antibody	Human	ELISA, FC

CD59 Proteins

CD59 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004947HU	Recombinant Human CD59 glycoprotein (CD59)	Yeast
CSB-EP004947HU	Recombinant Human CD59 glycoprotein (CD59)	E.coli
CSB-BP004947HU CSB-MP004947HU CSB-EP004947HU-B	Recombinant Human CD59 glycoprotein (CD59)	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD59 Proteins for Ovis aries (Sheep)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004947SH CSB-EP004947SH CSB-BP004947SH CSB-MP004947SH CSB-EP004947SH-B	Recombinant Sheep CD59 glycoprotein (CD59)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD59 Proteins for Oryctolagus cuniculus (Rabbit)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004947RB CSB-EP004947RB CSB-BP004947RB CSB-MP004947RB CSB-EP004947RB-B	Recombinant Rabbit CD59 glycoprotein (CD59)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD59 Proteins for Sus scrofa (Pig)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004947PI CSB-EP004947PI CSB-BP004947PI CSB-MP004947PI CSB-EP004947PI-B	Recombinant Pig CD59 glycoprotein (CD59)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD59 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004947RA CSB-EP004947RA CSB-BP004947RA CSB-MP004947RA CSB-EP004947RA-B	Recombinant Rat CD59 glycoprotein (Cd59)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD59 Proteins for Callithrix sp. (Marmoset)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004947CBD CSB-EP004947CBD CSB-BP004947CBD CSB-MP004947CBD CSB-EP004947CBD-B	Recombinant Callithrix sp. CD59 glycoprotein (CD59)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD59 Proteins for Aotus trivirgatus (Night monkey) (Douroucouli)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004947DNI CSB-EP004947DNI CSB-BP004947DNI CSB-MP004947DNI CSB-EP004947DNI-B	Recombinant Aotus trivirgatus CD59 glycoprotein (CD59)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD59 Proteins for Saimiri sciureus (Common squirrel monkey)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004947SWD CSB-EP004947SWD CSB-BP004947SWD CSB-MP004947SWD CSB-EP004947SWD-B	Recombinant Saimiri sciureus CD59 glycoprotein (CD59)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD59 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP630672DSU CSB-EP630672DSU CSB-BP630672DSU CSB-MP630672DSU CSB-EP630672DSU-B	Recombinant Chlorocebus aethiops CD59 glycoprotein (CD59)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD59 Proteins for Papio sp. (Baboon)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP631728PBS CSB-EP631728PBS CSB-BP631728PBS CSB-MP631728PBS CSB-EP631728PBS-B	Recombinant Papio sp. CD59 glycoprotein (CD59)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD59 Proteins for Pongo abelii (Sumatran orangutan)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP719114PYX CSB-EP719114PYX CSB-BP719114PYX CSB-MP719114PYX CSB-EP719114PYX-B	Recombinant Pongo abelii CD59 glycoprotein (CD59)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD59 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP823365MOV CSB-EP823365MOV CSB-BP823365MOV CSB-MP823365MOV CSB-EP823365MOV-B	Recombinant Macaca fascicularis CD59 glycoprotein (CD59)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli