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CD55

CD55,也被稱為衰變加速因子(DAF),是一種重要的補體調(diào)節(jié)蛋白,在人體內(nèi)發(fā)揮著關鍵的免疫保護作用。它屬于RCA(補體激活調(diào)節(jié)蛋白)家族,含有4到30個短共識重復(SCR)結構域,通過這些結構域參與多種生物過程。CD55主要通過抑制補體系統(tǒng)的激活來保護細胞免受攻擊。它能夠識別補體系統(tǒng)產(chǎn)生的C3b和C4b片段,通過與C4b結合抑制C2轉化為C2b,進而阻止C4b2a形成C3轉化酶,從而抑制C3轉化酶的形成。在替代途徑中,CD55與C3b結合后可以干擾D因子將B因子轉化為Bb,同樣阻止膜攻擊復合物的形成。CD55的這些作用機制有效地防止了補體級聯(lián)反應的過度激活,保護細胞免受補體攻擊。此外,CD55還參與腫瘤的發(fā)生發(fā)展,在多種癌癥中高表達,如前列腺癌、宮頸癌、乳腺癌等。CD55與CD97結合形成的復合物在腫瘤細胞的分化、遷移、浸潤及轉移中發(fā)揮重要作用?;贑D55在免疫系統(tǒng)和腫瘤生物學中的重要作用,CD55和CD97成為癌癥治療研究的新興靶點。目前,已有多種靶向CD55和CD97的藥物正在研發(fā)中,如CD55抗體可用于抑制結直腸癌和肺癌的惡化,CD55相關信號通路的抑制可增強其他治療藥物的抗腫瘤作用。此外,針對CD55缺乏蛋白丟失性腸?。–HAPLE?。┑闹委熕幬镆苍谘邪l(fā)中,如FDA已批準的新藥Veopoz,它是一種C5補體抑制劑,能靶向參與補體系統(tǒng)激活的蛋白質(zhì)補體因子C5,預防補體途徑介導的CHAPLE病。

熱銷產(chǎn)品

Recombinant Human Complement decay-accelerating factor (CD55), partial (CSB-EP004945HU1)

驗證數(shù)據(jù)

CSB-EP004945HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CD55 Recombinant Monoclonal Antibody (CSB-RA440943A0HU)

驗證數(shù)據(jù)

CSB-RA440943A0HU

Western Blot
Positive WB detected in: A549 whole cell lysate, 293T whole cell lysate, K562 whole cell lysate
All lanes: CD55 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 42, 49, 40, 57, 60 kDa
Observed band size: 70 kDa

CSB-RA440943A0HU

IHC image of CSB-RA440943A0HU diluted at 1:100 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA440943A0HU

IHC image of CSB-RA440943A0HU diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Human decay-accelerating factor(DAF/CD55)ELISA Kit (CSB-E05121h)

驗證數(shù)據(jù)

CSB-E05121h 標準曲線

貨號:CSB-E05121h

規(guī)格:96T/48T

靈敏度:0.09 ng/ml

檢測范圍:0.39 ng/ml- 25ng/ml

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CD55 Antibodies

CD55 for Homo sapiens (Human)

CD55 Proteins

CD55 Proteins for Homo sapiens (Human)

CD55 Proteins for Pongo pygmaeus (Bornean orangutan)

CD55 Proteins for Mus musculus (Mouse)

CD55 Proteins for Cavia porcellus (Guinea pig)

CD55 ELISA Kit

CD55 ELISA Kit for Homo sapiens (Human)