CD20
CD20，即B淋巴細胞抗原，別名MS4A1，是一種在B細胞表面表達的跨膜磷蛋白。它在B細胞的發(fā)育過程中，從前體B細胞到成熟B細胞的各個階段均有表達，但在漿細胞和造血干細胞中不表達。CD20在超過95%的B細胞淋巴瘤中高度表達，而在正常組織中表達較低，使其成為治療B細胞相關疾病的有效靶點。CD20的作用機制涉及調節(jié)B細胞的活化、增殖和分化?？笴D20單克隆抗體，如利妥昔單抗，通過激活補體系統(tǒng)和抗體依賴性細胞介導的細胞毒性作用（ADCC）來消滅B細胞來源的腫瘤細胞。此外，CD20還參與B細胞受體（BCR）的信號傳導，與多種細胞表面蛋白相互作用，對B細胞的生物學功能具有重要意義。
熱銷產品
Recombinant Human B-lymphocyte antigen CD20 (MS4A1) (CSB-CF015007HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
MS4A1 Recombinant Monoclonal Antibody (CSB-RA015007MA3HU)
驗證數據
The Binding Activity of Human MS4A1 with Anti-MS4A1 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human MS4A1 (CSB-MP015007HU) at 5 μg/mL can bind Anti-MS4A1 recombinant antibody, the EC50 is 6.959-19.70 ng/mL.
The Binding Activity of Dog MS4A1 with Anti-MS4A1 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Dog MS4A1 (CSB-MP661636DO) at 10 μg/mL can bind Anti-MS4A1 recombinant antibody, the EC50 is 147.3-199.0 ng/mL.
The Binding Activity of Macaca fascicularis CD20 with Anti-CD20 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis CD20 (CSB-MP4516MOV) at 10 μg/mL can bind Anti-CD20 recombinant antibody, the EC50 is 10.65-15.26 ng/mL.
The VLPs (CSB-MP3838) is negative control.
CD20 Antibodies
CD20 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA015007DSR2HU | MS4A1 Antibody | Human | ELISA, IHC |
| CSB-PA001433 | MS4A1 Antibody | Human | WB, ELISA |
| CSB-PA006161 | MS4A1 Antibody | Human | WB, ELISA |
| CSB-RA015007A0HU | CD20 Recombinant Monoclonal Antibody | Human | ELISA |
| CSB-MA996413 | MS4A1 Monoclonal Antibody | Human | ELISA, IHC |
| CSB-RA015007A1HU | MS4A1 Recombinant Monoclonal Antibody | Human | ELISA |
| CSB-RA015007MA3HU | MS4A1 Recombinant Monoclonal Antibody | Human, Dog, Macaca fascicularis | ELISA |
| CSB-RA015007MA4HU | MS4A1 Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF |
CD20 for H, M, R
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-MA000204 | MS4A1 Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
CD20 Proteins
CD20 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015007HU1 | Recombinant Human B-lymphocyte antigen CD20 (MS4A1), partial | Yeast |
| CSB-CF015007HU | Recombinant Human B-lymphocyte antigen CD20 (MS4A1) | in vitro E.coli expression system |
| CSB-EP015007HU1 CSB-BP015007HU1 CSB-MP015007HU1 CSB-EP015007HU1-B |
Recombinant Human B-lymphocyte antigen CD20 (MS4A1), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-MP015007HU | Recombinant Human B-lymphocyte antigen CD20 (MS4A1)-VLPs (Active) | Mammalian cell |
| CSB-EP015007HU2 | Recombinant Human B-lymphocyte antigen CD20 (MS4A1), partial | E.coli |
| CSB-MP015007HU-D | Recombinant Human B-lymphocyte antigen CD20(MS4A1)-Detergent (Active) | Mammalian cell |
CD20 ELISA Kit
CD20 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E14007h | Human B-lymphocyte antigen (CD20) ELISA Kit | serum, plasma, tissue homogenates | 0.78 ng/mL |
