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CCL1

CCL1,即C-C基序趨化因子配體1,別名I-309、P500、SCYA1、SISe、TCA3。CCL1是一種小糖蛋白,屬于CC趨化因子家族,分子量約為15-16 kDa。它由活化的單核細胞、巨噬細胞、T淋巴細胞和內(nèi)皮細胞分泌,對單核細胞具有趨化性,但對中性粒細胞無趨化作用。CCL1通過與細胞表面趨化因子受體CCR8相互作用,激活鈣離子流入,刺激單核細胞中細胞質(zhì)游離鈣濃度的短暫增加,并通過RAS/MAPK途徑抑制胸腺細胞系的細胞凋亡。CCL1通過白細胞募集參與炎癥過程,并在血管生成、病毒感染以及腫瘤發(fā)生等過程中發(fā)揮關鍵作用。CCL1基因中的一些單核苷酸多態(tài)性(SNP)與慢性阻塞性肺?。–OPD)的進展有關,CCL1在多種中樞神經(jīng)系統(tǒng)功能和疾病中發(fā)揮作用,與神經(jīng)炎癥障礙疾病相關。

熱銷產(chǎn)品

Recombinant Human C-C motif chemokine 1 (CCL1) (CSB-EP004774HUg4)

驗證數(shù)據(jù)

CSB-EP004774HUg4

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CCL1 Antibody (CSB-PA079873)

驗證數(shù)據(jù)

CSB-PA079873

The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA079873(CCL1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)

CSB-PA079873

The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA079873(CCL1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)

CCL1 Antibodies

CCL1 for Homo sapiens (Human)

CCL1 Proteins

CCL1 Proteins for Mus musculus (Mouse)

CCL1 Proteins for Homo sapiens (Human)

CCL1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

CCL1 ELISA Kit

CCL1 ELISA Kit for Homo sapiens (Human)

CCL1 ELISA Kit for Mus musculus (Mouse)