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CALR

CALR,全稱為鈣網蛋白(Calreticulin),是一種高度保守的內質網蛋白,主要參與蛋白質的折疊、組裝和質量控制。它通過與單葡萄糖基化糖蛋白相互作用,促進內質網中蛋白質的正確折疊,并介導NR3C1 DNA結合結構域的核輸出。CALR蛋白還參與細胞應激反應和免疫調節(jié),如與自身免疫性疾病的發(fā)生發(fā)展密切相關。在藥物研發(fā)方面,CALR蛋白已成為治療自身免疫性疾病和癌癥的重要靶點。例如,Cartesian Therapeutics公司開發(fā)的mRNA CAR-T細胞療法Descartes-08,通過靶向B細胞成熟抗原(BCMA),清除分泌自身抗體的漿細胞,在治療慢性自身免疫性疾病全身型重癥肌無力(MG)患者中取得了顯著療效。此外,Calreticulin/CALR蛋白也被用于開發(fā)針對急性髓系白血病(AML)的CAR-T療法,如羅斯威爾帕克癌癥研究所開發(fā)的抗CD83 CAR-T療法,已在1期臨床試驗階段,為AML患者提供了新的治療選擇。

熱銷產品

Recombinant Human Calreticulin (CALR) (CSB-MP004458HU)

驗證數據

CSB-MP004458HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CALR Recombinant Monoclonal Antibody (CSB-RA004458MA1HU)

驗證數據

CSB-RA004458MA1HU

Western Blot
Positive WB detected in: 293 whole cell lysate
All lanes: CALR antibody at 1:1000
Secondary
Goat polyclonal to mouse IgG at 1/50000 dilution
Predicted band size: 49 kDa
Observed band size: 49 kDa

CSB-RA004458MA1HU

IHC image of CSB-RA004458MA1HU diluted at 1:300 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA004458MA1HU

Immunofluorescence staining of HepG2 cell with CSB-RA004458MA1HU at 1:250, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).

CSB-RA004458MA1HU

Overlay Peak curve showing JK cells stained with CSB-RA004458MA1HU (red line) at 1:300. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,018 events was performed.

Human Calreticulin,CRT ELISA Kit (CSB-E09787h)

驗證數據

CSB-E09787h 標準曲線

貨號:CSB-E09787h

規(guī)格:96T/48T

靈敏度:0.039 ng/mL

檢測范圍:0.156 ng/mL-10 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CALR Antibodies

CALR for Homo sapiens (Human)

CALR for Pig

CALR Proteins

CALR Proteins for Mus musculus (Mouse)

CALR Proteins for Oryctolagus cuniculus (Rabbit)

CALR Proteins for Homo sapiens (Human)

CALR Proteins for Sus scrofa (Pig)

CALR Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

CALR Proteins for Bos taurus (Bovine)

CALR Proteins for Rattus norvegicus (Rat)

CALR Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

CALR Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

CALR Proteins for Macaca fuscata fuscata (Japanese macaque)

CALR Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

CALR ELISA Kit

CALR ELISA Kit for Homo sapiens (Human)