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C3

C3,即補體成分3,別名C3、C3adesArg、C3bc。C3是人體血漿中的主要補體成分之一,由肝臟細胞產(chǎn)生,是補體系統(tǒng)中心的蛋白質(zhì)。C3的作用機制包括作為補體級聯(lián)反應的中心環(huán)節(jié),它可以被多種途徑激活,包括經(jīng)典途徑、替代途徑和凝集素途徑。C3的激活導致其裂解為C3a和C3b兩個片段,其中C3b是效應片段,能夠結合到病原體表面,促進吞噬作用,而C3a則是一個強效的過敏毒素。C3是補體系統(tǒng)的關鍵組成部分,參與了機體的免疫防御機制。C3的激活可以促進病原體的清除,增強吞噬細胞對病原體的識別和吞噬,同時C3b片段還可以參與形成膜攻擊復合物(MAC),導致病原體細胞的溶解。此外,C3還參與調(diào)節(jié)炎癥反應,影響細胞黏附和細胞間相互作用。C3的異常調(diào)節(jié)與多種疾病有關,包括自身免疫性疾病、腎臟疾病和某些感染性疾病,因此,C3是免疫學研究和相關疾病治療中的一個潛在靶點。

熱銷產(chǎn)品

Recombinant Human Complement C3 (C3), partial (CSB-EP355590HU)

驗證數(shù)據(jù)

CSB-EP355590HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP355590HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-RP105994h could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) C3.

CSB-EP355590HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-RP105994h could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) C3.

C3 Recombinant Monoclonal Antibody (CSB-RA303909A0HU)

驗證數(shù)據(jù)

CSB-RA303909A0HU

Western Blot
Positive WB detected in: THP-1 whole cell lysate, K562 whole cell lysate
All lanes: C3 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 188 kDa
Observed band size: 115 kDa

CSB-RA303909A0HU

IHC image of CSB-RA303909A0HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA303909A0HU

Overlay histogram showing HepG2 cells stained with CSB-RA303909A0HU (red line) at 1:50. The cells were fixed with 70% Ethylalcohol (18h) and then incubated in 10% normal goat serum to block non-specific protein-protein interactions followedby the antibody (1μg/1*106 cells) for 1 h at 4℃.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4℃. Control antibody (green line) was Rabbit IgG (1μg/1*106 cells) used under the same conditions. Acquisition of >10,000 events was performed.

C3 Antibodies

C3 for Homo sapiens (Human)

C3 for Mus musculus (Mouse)

C3 for Rattus norvegicus (Rat)

C3 Proteins

C3 Proteins for Oryctolagus cuniculus (Rabbit)

C3 Proteins for Sus scrofa (Pig)

C3 Proteins for Eptatretus burgeri (Inshore hagfish)

C3 Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)

C3 Proteins for Cavia porcellus (Guinea pig)

C3 Proteins for Enterobacteria phage P22 (Bacteriophage P22)

C3 Proteins for Clostridium botulinum D phage (Clostridium botulinum D bacteriophage)

C3 Proteins for Beet curly top virus (strain California/Logan) (BCTV)

C3 Proteins for Tomato yellow leaf curl virus (strain Israel) (TYLCV)

C3 Proteins for Xenopus laevis (African clawed frog)

C3 Proteins for Tomato leaf curl virus (strain Australia) (ToLCV)

C3 Proteins for Tomato yellow leaf curl Sardinia virus (TYLCSV)

C3 Proteins for Tomato yellow leaf curl Sardinia virus (isolate Spain-1) (TYLCSV)

C3 Proteins for Homo sapiens (Human)

C3 Proteins for Caiman crocodilus (Spectacled caiman) (Caiman sclerops)

C3 Proteins for Rattus norvegicus (Rat)

C3 Proteins for Bos taurus (Bovine)

C3 Proteins for Clostridium limosum

C3 Proteins for Microplitis demolitor bracovirus (isolate Webb) (MdBV)

C3 Proteins for Tomato yellow leaf curl Sardinia virus (isolate Spain-2) (TYLCSV)

C3 Proteins for Tomato pseudo-curly top virus (TPCTV)

C3 Proteins for Tomato yellow leaf curl China virus (TYLCCNV)

C3 Proteins for Mus musculus (Mouse)

C3 ELISA Kit

C3 ELISA Kit for Homo sapiens (Human)

C3 ELISA Kit for Monkey

C3 ELISA Kit for Mus musculus (Mouse)

C3 ELISA Kit for Rattus norvegicus (Rat)

C3 ELISA Kit for Sus scrofa (Pig)