RTN4，即Reticulon 4，別名Neurite Growth Inhibitor 220、My043等。RTN4是一種在多種組織中表達(dá)的內(nèi)質(zhì)網(wǎng)相關(guān)蛋白，尤其在神經(jīng)系統(tǒng)中，它作為一種神經(jīng)突起生長抑制劑，參與調(diào)節(jié)神經(jīng)再生。RTN4的作用機(jī)制涉及調(diào)節(jié)內(nèi)質(zhì)網(wǎng)形態(tài)，影響內(nèi)質(zhì)網(wǎng)腔內(nèi)物質(zhì)的運(yùn)輸，包括鈣離子等，進(jìn)而影響細(xì)胞功能。RTN4在神經(jīng)系統(tǒng)發(fā)育、神經(jīng)元存活、細(xì)胞骨架調(diào)節(jié)以及腫瘤發(fā)展等方面都具有重要作用。研究發(fā)現(xiàn)，RTN4的表達(dá)與多種癌癥的發(fā)生發(fā)展相關(guān)，例如在肺癌、乳腺癌、宮頸癌和腎癌中，較低的RTN4表達(dá)與患者生存率的提高相關(guān)。此外，RTN4還參與調(diào)節(jié)血管生成和神經(jīng)修復(fù)過程。在膠質(zhì)瘤中，RTN4的表達(dá)與腫瘤的惡性增殖行為相關(guān)，可能通過影響細(xì)胞周期相關(guān)蛋白的表達(dá)來調(diào)控膠質(zhì)瘤細(xì)胞的增殖。

熱銷產(chǎn)品

RTN4 Recombinant Monoclonal Antibody (CSB-RA878853MA1HU)

驗(yàn)證數(shù)據(jù)

Overlay Peak curve showing A549 cells stained with CSB-RA878853MA1HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*10⁶cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-human IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was human IgG (1ug/1*10⁶cells) used under the same conditions. Acquisition of >10,000 events was performed.

Human Reticulon-4(RTN4) ELISA kit (CSB-EL020572HU)

驗(yàn)證數(shù)據(jù)

貨號：CSB-EL020572HU

規(guī)格：96T/48T

靈敏度：11.75 pg/mL

檢測范圍：46.88 pg/mL-3000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.