白細(xì)胞介素10受體α亞基（IL10RA）是調(diào)控免疫穩(wěn)態(tài)的關(guān)鍵膜蛋白，也被稱為CDW210A或IL-10R1。它通過與細(xì)胞因子IL-10特異性結(jié)合，抑制促炎因子釋放，維持機(jī)體炎癥與抗炎反應(yīng)的動(dòng)態(tài)平衡。IL10RA在巨噬細(xì)胞、T淋巴細(xì)胞等免疫細(xì)胞表面廣泛表達(dá)，其功能缺陷可能導(dǎo)致嬰兒期炎癥性腸病、極早發(fā)型克羅恩病等遺傳性腸道病變。近年來，科研人員發(fā)現(xiàn)IL10RA基因突變與部分原發(fā)性免疫缺陷綜合征密切相關(guān)，這類患者常表現(xiàn)為反復(fù)感染或組織損傷。在藥物開發(fā)領(lǐng)域，基于IL-10信號通路的新型生物制劑已進(jìn)入臨床研究階段，部分候選藥物在銀屑病、類風(fēng)濕關(guān)節(jié)炎等自身免疫性疾病中展現(xiàn)出調(diào)節(jié)過度免疫反應(yīng)的潛力。此外，針對受體結(jié)構(gòu)的分子優(yōu)化策略正在探索，旨在提高IL-10類似物的靶向性和穩(wěn)定性。

熱銷產(chǎn)品

Recombinant Human Interleukin-10 receptor subunit alpha (IL10RA), partial (CSB-MP621688HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

IL10RA Antibody (CSB-PA621688ESR2HU)

驗(yàn)證數(shù)據(jù)

Western blot
All lanes: Interleukin-10 receptor subunit alpha antibody at 8μg/ml
Lane 1: Mouse heart tissue
Lane 2: Hela whole cell lysate
Lane 3: Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 63 kDa
Observed band size: 63 kDa

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA621688ESR2HU at dilution of 1:100