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STAMBP Antibody

  • 中文名稱：
    STAMBP兔多克隆抗體
  • 貨號(hào)：
    CSB-PA022794HA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: STAMBP antibody at 12µg/ml
      Lane 1: Jurkat whole cell lysate
      Lane 2: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 49, 40 kDa
      Observed band size: 49 kDa
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA022794HA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA022794HA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) STAMBP Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    AMSH antibody; Associated molecule with the SH3 domain of STAM antibody; Endosome associated ubiquitin isopeptidase antibody; Endosome-associated ubiquitin isopeptidase antibody; MGC126516 antibody; MGC126518 antibody; MICCAP antibody; STABP_HUMAN antibody; STAM binding protein antibody; STAM-binding protein antibody; Stambp antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human STAM-binding protein (1-424AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，STAMBP Antibody (CSB-PA022794HA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于STAMBP Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA022794HB01HU STAMBP Antibody, HRP conjugated ELISA
    FITC CSB-PA022794HC01HU STAMBP Antibody, FITC conjugated
    Biotin CSB-PA022794HD01HU STAMBP Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.
  • 基因功能參考文獻(xiàn)：
    1. Contrary to previously reported STAMBP mutations, the Ser236Phe mutation did not lead to constitutive activation of the PI3K-AKT-mTOR pathway in patient-derived LCLs, as indicated by the expression of phosphorylated S6 ribosomal protein, suggesting that it is not the major pathomechanism underlying the disorder in this patient. PMID: 29907875
    2. Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity. PMID: 28492230
    3. Two siblings with classic features of MIC-CAP syndrome that harbor a novel predicted splice mutation in STAMBP PMID: 25692795
    4. associated molecule with the SH3 domain of STAM-mediated deubiquitination of connexin 43 protects Gap junctions from degradation PMID: 25070368
    5. Recognition of the proximal ubiquitin is imperative for the linkage specificity and catalytic efficiency of AMSH. PMID: 24151880
    6. Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly-capillary malformation syndrome. PMID: 23542699
    7. AMSH efficiently removes ubiquitin from the activated EGFR. PMID: 22800866
    8. tight coupling of ESCRT-III CHMP3 and AMSH functions and provide insight into the regulation of ESCRT-III PMID: 21827950
    9. Studies indicate that USP8/Ubpy and AMSH interact with ESCRT components to modulate the ubiquitination status of receptors and relevant sorting proteins. PMID: 21448666
    10. AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4. PMID: 20159979
    11. AMSH is a deubiquitinating enzyme with functions at the endosome to oppose ubiquitin-dependent receptor sorting PMID: 15314065
    12. The cellular functions of UBPY are complex but clearly distinct from those of the Lys-63-ubiquitin-specific protease, AMSH, with which it shares a binding site on the SH3 domain of STAM PMID: 16520378
    13. AMSH and AMSH-LP are anchored on the early endosomal membrane via interaction with the clathrin coat PMID: 16716190
    14. AMSH has a role in the deubiquitination of the endosomal cargo preceding lysosomal degradation PMID: 16760479
    15. AMSH, which has been recently characterized as a regulator of the endosomal sorting of epidermal growth factor receptor, represents a novel modulator of CaR signaling. PMID: 16854379
    16. both the deubiquitination enzyme activity of AMSH and its CHMP3-binding ability are required to clear ubiquitinated cargo from endosomes PMID: 17159328
    17. Endosomal AMSH (STAMBP) is a functional component of the multivesicular body pathway. PMID: 17261583
    18. UBPY MIT domain and another ubiquitin isopeptidase, AMSH, reveals common interactions with CHMP1A and CHMP1B but a distinct selectivity of AMSH for CHMP3/VPS24, a core subunit of the ESCRT-III complex, and UBPY for CHMP7. PMID: 17711858
    19. crystal structures of the human AMSH-LP DUB domain alone and in complex with a Lys 63-linked di-ubiquitin at 1.2 A and 1.6 A resolutions, respectively PMID: 18758443
    20. Data suggest that AMSH and UBPY are essential for trafficking and down-regulation of PAR(2) but not for regulating PAR(2) dissociation from beta-arrestin2 or PAR(2)-mediated ERK2 activation. PMID: 19684015

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  • 相關(guān)疾?。?/div>
    Microcephaly-capillary malformation syndrome (MICCAP)
  • 亞細(xì)胞定位：
    Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome.
  • 蛋白家族：
    Peptidase M67C family
  • 組織特異性：
    Ubiquitously expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 16950

    OMIM: 606247

    KEGG: hsa:10617

    STRING: 9606.ENSP00000344742

    UniGene: Hs.469018