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  4. Rat Podocalyxin,PCX ELISA Kit

Rat Podocalyxin,PCX ELISA Kit

  • 中文名稱：
    大鼠足細(xì)胞標(biāo)記蛋白/足盂蛋白(PCX)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E13946r
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠足細(xì)胞標(biāo)記蛋白/足盂蛋白(PCX)酶聯(lián)免疫試劑盒（CSB-E13946r）為雙抗夾心法ELISA試劑盒，定量檢測血清、尿液、組織培養(yǎng)上清液樣本中的PODXL含量。PODXL即足糖萼蛋白，它是一種跨膜蛋白，在胚胎發(fā)育等過程發(fā)揮作用。研究顯示它與腫瘤發(fā)生、發(fā)展密切相關(guān)，可促進(jìn)腫瘤細(xì)胞增殖、遷移和侵襲，還能影響腫瘤血管生成，有望成為癌癥診斷標(biāo)志物和治療靶點(diǎn)，為癌癥防治提供新思路。試劑盒檢測范圍為1.56 ng/mL-100 ng/mL，科研人員可通過動態(tài)監(jiān)測實(shí)驗(yàn)動物或細(xì)胞模型中PCX的表達(dá)變化，用于探究腎臟疾病發(fā)生發(fā)展機(jī)制、評估藥物干預(yù)效果或建立體外足細(xì)胞損傷模型等基礎(chǔ)研究。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Podxl ELISA Kit; Pclp1 ELISA Kit; Podocalyxin ELISA Kit; Podocalyxin-like protein 1 ELISA Kit; PC ELISA Kit; PCLP-1 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, urine, cell culture supernates
  • 檢測范圍：
    1.56 ng/mL-100 ng/mL
  • 靈敏度：
    0.39 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cancer
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat PCX in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %87
    Range %81-93
    1:2Average %97
    Range %93-101
    1:4Average %89
    Range %85-93
    1:8Average %98
    Range %92-104
  • 回收率：
    The recovery of rat PCX spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9185-97
    EDTA plasma (n=4)8983-94
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    1002.201 2.312 2.257 2.112
    501.574 1.456 1.515 1.370
    251.009 1.056 1.033 0.888
    12.50.633 0.654 0.644 0.499
    6.250.401 0.412 0.407 0.262
    3.120.272 0.286 0.279 0.134
    1.560.210 0.215 0.213 0.068
    00.144 0.146 0.145
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
  • 基因功能參考文獻(xiàn)：
    1. podocalyxin has a role in defining the structure of the podocyte basal surface PMID: 15226400
    2. Podocalyxin might be associated with the malignant progression of astrocytic tumors, and be a useful prognostic marker for astrocytic tumors. PMID: 18639524
    3. Report ubiquitous yet distinct expression of podocalyxin on vascular surfaces in normal and tumor tissues in the rat. PMID: 19142011
  • 亞細(xì)胞定位：
    Apical cell membrane. Cell projection, microvillus. Membrane raft. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle. Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Podocalyxin family
  • 組織特異性：
    Glomerular epithelium cell (podocyte) (at protein level).
  • 數(shù)據(jù)庫鏈接：