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  4. Mouse lymphotactin,Lptn/LTN ELISA Kit

Mouse lymphotactin,Lptn/LTN ELISA Kit

  • 中文名稱：
    小鼠淋巴細胞趨化因子(Lptn/LTN/XCL1)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E08714m
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3800/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠淋巴細胞趨化因子(Lptn/LTN/XCL1)酶聯(lián)免疫試劑盒（CSB-E08714m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的XCL1含量。試劑盒檢測范圍為0.156 ng/ml- 10 ng/ml，適用于小鼠模型中的免疫機制研究，如炎癥反應評估、免疫細胞遷移實驗或免疫治療相關基礎研究?？蒲腥藛T可通過系統(tǒng)性分析不同病理生理條件下XCL1的動態(tài)變化，為免疫調(diào)控機制研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Xcl1 ELISA Kit; Lptn ELISA Kit; Ltn ELISA Kit; Scyc1 ELISA Kit; Lymphotactin ELISA Kit; C motif chemokine 1 ELISA Kit; Cytokine SCM-1 ELISA Kit; Lymphotaxin ELISA Kit; Small-inducible cytokine C1 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.156 ng/ml - 10 ng/ml
  • 靈敏度：
    0.039 ng/ml
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.
  • 基因功能參考文獻：
    1. study provides in vitro and in vivo evidence that the interaction between XCL1 and alpha9 integrin has an important role for autoimmune diseases PMID: 28550205
    2. The interaction between XCL1 and XCR1 plays a crucial role in the classical immunology response. PMID: 27387353
    3. Data show that mice lacking either XCL1 or XCR1 exhibit similar specific defects in intestinal T cell populations as XCR1-dendritic cells (DC)-deficient mice. Therefore it is possible that the XCR1-XCL1 axis itself is directly involved in intestinal T cell homeostasis, via a mechanism that might either involve interaction with XCR1+ DCs or be independent of this pathway. PMID: 27005831
    4. T inflammatory memory CD8 T cells participate to antiviral response and generate secondary memory cells with an advantage in XCL1 production PMID: 22528127
    5. XCL1-mediated accumulation of dendritic cells in the thymic medulla contributes to naturally occurring regulatory T cell development and is regulated by Aire. PMID: 21300913
    6. Data report the identification of a new stable molecular assembly formed between the ATAC and Mediator complexes in mouse embryonic stem cells. PMID: 20508642
    7. The expression patterns of XCR1 and XCL1 were conserved in human and mice blood cells, including certain dendritic cell subsets. PMID: 20541533
    8. MIP-1alpha, MIP-1beta, RANTES, and ATAC/lymphotactin function together with IFN-gamma as type 1 cytokines. PMID: 11972057
    9. Adenovirus-mediated intratumoral Lptn gene transfer potentiates the antibody-targeted superantigen therapy of experimental melanoma. PMID: 12226740
    10. In a brain-targeted HIV-1 Tat transgenic model, Tat expression up-regulates XCL1 production not only in Tat-expressing murine astrocytes, but also in monocytes and macrophages/microglia. PMID: 14734774
    11. Lymphotactin gene-modified dendritoma induces T-cell proliferation and strong cytotoxic T lymphocytes reaction against allogenic hepatocellular carcinoma cells. PMID: 17990361
    12. Results describe the role of XCL1 during the course of the immune response to pulmonary M. tuberculosis infection. PMID: 19097989

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine gamma family
  • 組織特異性：
    Expressed in activated CD8(+) T cells. In the thymus, expressed by medullary thymic epithelial cells.
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:16963

    STRING: 10090.ENSMUSP00000027860

    UniGene: Mm.190