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  4. Monkey Proprotein convertase subtilisin/kexin type 9(PCSK9) ELISA kit

Monkey Proprotein convertase subtilisin/kexin type 9(PCSK9) ELISA kit

  • 中文名稱：
    猴前蛋白轉化酶枯草溶菌素9(PCSK9)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL017647RH
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥4200/￥3000
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    猴前蛋白轉化酶枯草溶菌素9(PCSK9)酶聯(lián)免疫試劑盒（CSB-EL017647RH）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的PCSK9含量。PCSK9是一種重要靶點。其背景在于它與血脂代謝密切相關，PCSK9基因變異可影響體內(nèi)膽固醇水平。研究機制顯示，它能與低密度脂蛋白受體結合，促進其降解，減少肝臟對低密度脂蛋白膽固醇清除，針對它開發(fā)藥物可降低血脂，防治心血管疾病。試劑盒檢測范圍為1.1 pg/mL-800 pg/mL，可廣泛應用于基礎科研領域，包括心血管疾病模型研究、代謝綜合征機制探索、脂質(zhì)代謝相關藥物開發(fā)中的生物標志物檢測，以及動物實驗中PCSK9蛋白表達水平的動態(tài)監(jiān)測，為深入解析其生理功能及病理機制提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    PCSK9 ELISA Kit; Proprotein convertase subtilisin/kexin type 9 ELISA Kit; EC 3.4.21.- ELISA Kit; Proprotein convertase 9 ELISA Kit; PC9 ELISA Kit; Subtilisin/kexin-like protease PC9 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Monkey
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    1.1 pg/mL-800 pg/mL
  • 靈敏度：
    1.1 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Metabolism
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess. 
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
     
  • 標準曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways.
  • 亞細胞定位：
    Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus.
  • 蛋白家族：
    Peptidase S8 family
  • 數(shù)據(jù)庫鏈接：

    KEGG: mcc:717147

    UniGene: Mmu.17333