Monkey Interleukin 15,IL-15 ELISA Kit

文獻引用 (2) 說明書下載

產(chǎn)品詳情

產(chǎn)品描述：

猴子白介素15(IL-15)酶聯(lián)免疫試劑盒（CSB-E14392Mk）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿樣本中的IL15含量。IL15即白介素-15，是一種具有廣泛生物學(xué)活性的細胞因子。它在免疫調(diào)節(jié)中扮演著關(guān)鍵角色，能促進T細胞、NK細胞的增殖、存活和活化。目前針對IL15的研究聚焦于其信號傳導(dǎo)機制，有望以此為靶點開發(fā)免疫治療藥物，用于對抗腫瘤等疾病。試劑盒檢測范圍為15.6 pg/mL-1000 pg/mL，評估靈長類動物感染性疾病模型、疫苗免疫效果或免疫治療研究中的免疫狀態(tài)；適用于非人靈長類動物（如食蟹猴、恒河猴）的免疫機制研究、炎癥性疾病模型構(gòu)建及生物制劑藥效評價等科研領(lǐng)域，為探索IL-15在先天性與適應(yīng)性免疫中的調(diào)控作用提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
別名：

IL15 ELISA Kit; Interleukin-15 ELISA Kit; IL-15 ELISA Kit
縮寫：

IL15
Uniprot No.：

P48092
種屬：

Monkey
樣本類型：

serum, plasma
檢測范圍：

15.6 pg/mL-1000 pg/mL
靈敏度：

3.9 pg/mL
反應(yīng)時間：

1-5h
樣本體積：

50-100ul
檢測波長：

450 nm
研究領(lǐng)域：

Immunology
測定原理：

quantitative
測定方法：

Sandwich

精密度：

Intra-assay Precision (Precision within an assay): CV%<8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV%<10%
Three samples of known concentration were tested in twenty assays to assess.

標準曲線：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

功能：

Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA. In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation.
基因功能參考文獻：
1. IL 15 generates a dramatic expansion of short-lived memory CD8 T cells and natural killer in immunocompetent macaques and has long-term effects on the balance of CD4(+) and CD8(+) T cells. PMID: 20631381
2. These data suggest that therapeutic use of IL-15 in the setting of antiretroviral therapy might facilitate specific restoration of the CD4 + T cell compartment. PMID: 16691294
3. IL-15 secretion significantly correlates with the up-regulated expression of CD4 on memory CD4 T cells that is associated with increased permissiveness to simian immunodeficiency virus infection. PMID: 19155491
亞細胞定位：

Secreted.
蛋白家族：

IL-15/IL-21 family
數(shù)據(jù)庫鏈接：

KEGG: mcc:699616

STRING: 9544.ENSMMUP00000025100

UniGene: Mmu.3414