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  4. Human Chitinase-3-like protein 2(CHI3L2) ELISA kit

Human Chitinase-3-like protein 2(CHI3L2) ELISA kit

  • 中文名稱：
    人幾丁質(zhì)酶3樣蛋白2(CHI3L2)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL005347HU
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人幾丁質(zhì)酶3樣蛋白2(CHI3L2)酶聯(lián)免疫試劑盒（CSB-EL005347HU）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的CHI3L2含量。CHI3L2是一種糖基水解酶家族成員，缺乏酶活性，通過結(jié)合多糖和細(xì)胞表面受體調(diào)控炎癥、組織重塑和腫瘤微環(huán)境。在關(guān)節(jié)炎、纖維化疾病和惡性腫瘤中高表達(dá)，是疾病進(jìn)展的生物標(biāo)志物和潛在治療靶點(diǎn)。試劑盒檢測(cè)范圍為0.78 ng/ml-50 ng/ml，該產(chǎn)品可為炎癥性疾病機(jī)制研究、纖維化模型評(píng)估或腫瘤微環(huán)境分析提供關(guān)鍵生物標(biāo)志物檢測(cè)支持，特別適用于基礎(chǔ)醫(yī)學(xué)、免疫學(xué)及分子病理學(xué)領(lǐng)域的體外樣本檢測(cè)，幫助研究者探索CHI3L2在疾病發(fā)生發(fā)展中的調(diào)控作用。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    CH3L2_HUMAN ELISA Kit; CHI3L2 ELISA Kit; Chitinase 3 like 2 ELISA Kit; Chitinase-3-like protein 2 ELISA Kit; Chondrocyte protein 39 ELISA Kit; OTTHUMP00000014028 ELISA Kit; YKL 39 ELISA Kit; YKL-39 ELISA Kit; YKL39 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    0.78 ng/ml-50 ng/ml
  • 靈敏度：
    0.19 ng/ml
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長：
    450 nm
  • 研究領(lǐng)域：
    Stem Cells
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

  • 線性度：

    To assess the linearity of the assay, samples were spiked with high concentrations of human CHI3L2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

    　

    Sample

    Serum(n=4)

    1:1

    Average %

    87

    Range %

    81-91

    1:2

    Average %

    101

    Range %

    95-105

    1:4

    Average %

    102

    Range %

    98-109

    1:8

    Average %

    96

    Range %

    91-98

  • 回收率：

    The recovery of human CHI3L2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range

    Serum (n=5)

    94

    89-96

    EDTA plasma (n=4)

    96

    91-98

  • 標(biāo)準(zhǔn)曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    ng/ml

    OD1

    OD2

    Average

    Corrected

    50

    2.701

    2.688

    2.695

    2.582

    25

    2.344

    2.192

    2.268

    2.155

    12.5

    1.704

    1.729

    1.717

    1.604

    6.25

    1.151

    1.137

    1.144

    1.031

    3.125

    0.678

    0.699

    0.689

    0.576

    1.56

    0.388

    0.366

    0.377

    0.264

    0.78

    0.238

    0.241

    0.240

    0.127

    0

    0.115

    0.111

    0.113

    　

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity.
  • 基因功能參考文獻(xiàn)：
    1. This study shown that CHI3L2 is regulated differently in healthy and late onset Alzheimer"s disease brain depending on the sex. PMID: 27653898
    2. Structural analysis demonstrates that YKL-39 interacts with chitooligosaccharides through hydrogen bonds and hydrophobic interactions. Thermodynamic analysis indicates that binding of chitooligosaccharide to YKL-39 is mainly driven by enthalpy. PMID: 25477513
    3. These data suggest that hYKL-39 is a novel growth and differentiation factor involved in cartilage homeostasis. PMID: 23291184
    4. YKL-39 possesses a chitinase-like fold, but lacks key active-site residues required for catalysis. PMID: 22742450
    5. ERK1/2 phosphorylation by CHI3L2 inhibits cell mitogenesis and proliferation. PMID: 22211103

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Glycosyl hydrolase 18 family
  • 組織特異性：
    Highest expression in chondrocytes, followed by synoviocytes, lung and heart. Not detected in spleen, pancreas, and liver. May also be expressed in developing brain and placenta.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1933

    OMIM: 601526

    KEGG: hsa:1117

    STRING: 9606.ENSP00000358763

    UniGene: Hs.514840