MMP14
MMP14，即基質(zhì)金屬蛋白酶14，別名MT1-MMP。它由人類MMP14基因編碼，位于染色體12上。MMP14是一種膜型基質(zhì)金屬蛋白酶，主要在細(xì)胞表面發(fā)揮作用，通過其催化活性區(qū)含有的鋅離子結(jié)合位點(diǎn)，對(duì)酶催化作用的發(fā)揮至關(guān)重要。MMP14的作用機(jī)制包括激活其他MMPs（如MMP2），參與細(xì)胞外基質(zhì)的重塑，影響腫瘤的侵襲和轉(zhuǎn)移。MMP14參與組織發(fā)育、生殖、組織重塑等正常生理過程，同時(shí)在疾病過程中如關(guān)節(jié)炎、腫瘤轉(zhuǎn)移中發(fā)揮作用。MMP14的表達(dá)水平在多種腫瘤中上調(diào)，與腫瘤的預(yù)后密切相關(guān)，如在胰腺癌、肝癌等腫瘤中高表達(dá)與不良預(yù)后相關(guān)。此外，MMP14還參與調(diào)節(jié)免疫反應(yīng)和炎癥過程。
熱銷產(chǎn)品
Recombinant Human Matrix metalloproteinase-14 (MMP14) (CSB-EP014661HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP014661HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MMP14.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP014661HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MMP14.
MMP14 Antibody (CSB-PA014661ESR1HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA014661ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA014661ESR1HU at dilution of 1:100
MMP14 Antibodies
MMP14 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA014661GA01HU | MMP14 Antibody | Human,Mouse,Rat,Zebrafish | ELISA,WB |
| CSB-PA12389D0Rb | MMP14 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA12389A0Rb | MMP14 Antibody | Human | ELISA, IHC |
| CSB-PA014661ESR1HU | MMP14 Antibody | Human | ELISA, IHC |
| CSB-PA897896 | MMP14 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA000050 | Cleaved-MMP14 (Y112) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA010212 | MMP14 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA971298 | MMP14 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA553918 | MMP14 Antibody | Human,Mouse,Rat | ELISA,IHC |
MMP14 Proteins
MMP14 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP014661HU CSB-BP014661HU CSB-MP014661HU CSB-EP014661HU-B |
Recombinant Human Matrix metalloproteinase-14 (MMP14), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP014661HU | Recombinant Human Matrix metalloproteinase-14 (MMP14) | E.coli |
| CSB-CF014661HU | Recombinant Human Matrix metalloproteinase-14 (MMP14) | in vitro E.coli expression system |
MMP14 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP014661MO1 CSB-EP014661MO1 CSB-BP014661MO1 CSB-MP014661MO1 CSB-EP014661MO1-B |
Recombinant Mouse Matrix metalloproteinase-14 (Mmp14), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF014661MO | Recombinant Mouse Matrix metalloproteinase-14 (Mmp14) | in vitro E.coli expression system |
MMP14 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP608834RA CSB-EP608834RA CSB-BP608834RA CSB-MP608834RA CSB-EP608834RA-B |
Recombinant Rat Matrix metalloproteinase-14 (Mmp14), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MMP14 Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP725453PYX CSB-EP725453PYX CSB-BP725453PYX CSB-MP725453PYX CSB-EP725453PYX-B |
Recombinant Pongo abelii Matrix metalloproteinase-14 (MMP14), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MMP14 Proteins for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP839160RB CSB-EP839160RB CSB-BP839160RB CSB-MP839160RB CSB-EP839160RB-B |
Recombinant Rabbit Matrix metalloproteinase-14 (MMP14), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MMP14 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP884395BO CSB-EP884395BO CSB-BP884395BO CSB-MP884395BO CSB-EP884395BO-B |
Recombinant Bovine Matrix metalloproteinase-14 (MMP14), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MMP14 Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP896435PI CSB-EP896435PI CSB-BP896435PI CSB-MP896435PI CSB-EP896435PI-B |
Recombinant Pig Matrix metalloproteinase-14 (MMP14), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
