GAD1

GAD1，即谷氨酸脫羧酶1，別名GAD67。這是一種在大腦中表達的酶，負責催化谷氨酸轉化為抑制性神經(jīng)遞質(zhì)γ-氨基丁酸（GABA）。GAD1在神經(jīng)系統(tǒng)和內(nèi)分泌系統(tǒng)中表達，涉及突觸傳遞和胰島素分泌。在腫瘤學中，GAD1在多種腫瘤中異常上調(diào)表達，其高表達與結直腸癌的臨床分期及生存時間密切相關，并可能在腫瘤細胞適應低氧、低pH微環(huán)境中起重要作用。GAD1的異常表達可能通過影響CTCF與DNA的結合，改變基因的甲基化模式，從而激活基因表達。在腫瘤細胞中，GAD1可能通過調(diào)節(jié)氨基酸穩(wěn)態(tài)來支持細胞增殖，這一作用與其在GABA代謝中的角色不同。GAD1的這些功能在調(diào)節(jié)神經(jīng)系統(tǒng)功能和腫瘤生物學中具有重要的生物學意義。

熱銷產(chǎn)品

GAD1 Antibody (CSB-PA858702ESR1HU)

驗證數(shù)據(jù)

Western blot
All lanes: Glutamate decarboxylase 1 antibody at 8μg/ml + HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 67, 26, 48 kDa
Observed band size: 67 kDa

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA858702ESR1HU at dilution of 1:100

Human glutamic acid decarboxylase,GAD ELISA Kit (CSB-E09199h)

驗證數(shù)據(jù)

貨號：CSB-E09199h

規(guī)格：96T/48T

靈敏度：0.078 ng/mL

檢測范圍：0.312 ng/mL-20 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

GAD1 Antibody

GAD1 Protein

GAD1 ELISA Kit

GAD1 Antibodies

GAD1 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應性	應用類型
CSB-PA858702ESR1HU	GAD1 Antibody	Human	ELISA, WB, IHC
CSB-PA858702ESR2HU	GAD1 Antibody	Human, Rat	ELISA, WB, IHC
CSB-PA087198	GAD1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA142729	GAD1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA008568	GAD1 Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA102201	GAD1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA219867	GAD1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA981570	GAD1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC

GAD1 Proteins

GAD1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP858702HU CSB-EP858702HU CSB-BP858702HU CSB-MP858702HU CSB-EP858702HU-B	Recombinant Human Glutamate decarboxylase 1 (GAD1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli